Seroprevalence to the circumsporozoite protein peptide antigen of Plasmodium vivax in Korean children

Chae Seung Lim, Jae Kyun Yoon, Eun Ah Chang, In Bum Suh, Seong Soo A An, Kee Hyoung Lee, Ji-Tae Choung, Young Chang Tockgo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recently, malaria re-emerged in the Republic of Korea (ROK), but there have been only a few reports on malaria seroprevalence. For the epidemiological study in children, a total of 1,176 serum samples were obtained from children and adolescent inhabitants from the three different regions, Pajoo, the Guro district in the western part of Seoul (Guro), and Ansan, from June to September 2002, when the transmission rate was high. Anti-circumsporozoite protein (CSP) antibody levels were assessed in samples using an indirect enzyme-linked immunosorbent assay (ELISA) method. Among the three regions, the highest IgG seroreactivity against the CSP antigen of Plasmodium vivax was found in the children from Pajoo (8.0%), followed by the children from Guro (3.2%), and those in Ansan (0.02%) had the lowest seroreactivity. In Pajoo, the profile of antibody response showed the highest in age 9, but decreased with age towards 12 years old. We found significant correlation between the seroprevalence and annual incidence in the investigated areas, suggesting that the area-related patterns reflected the differences of inoculation rates in children.

Original languageEnglish
Pages (from-to)521-527
Number of pages7
JournalMicrobiology and Immunology
Volume49
Issue number6
Publication statusPublished - 2005 Jul 19

Fingerprint

Plasmodium vivax
Seroepidemiologic Studies
Antigens
Peptides
Proteins
Malaria
Republic of Korea
Antibody Formation
Epidemiologic Studies
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Antibodies
Incidence
Serum

Keywords

  • Children
  • Circumsporozoite protein
  • Plasmodium vivax
  • Republic of Korea
  • Seroprevalence

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Microbiology

Cite this

Lim, C. S., Yoon, J. K., Chang, E. A., Suh, I. B., An, S. S. A., Lee, K. H., ... Tockgo, Y. C. (2005). Seroprevalence to the circumsporozoite protein peptide antigen of Plasmodium vivax in Korean children. Microbiology and Immunology, 49(6), 521-527.

Seroprevalence to the circumsporozoite protein peptide antigen of Plasmodium vivax in Korean children. / Lim, Chae Seung; Yoon, Jae Kyun; Chang, Eun Ah; Suh, In Bum; An, Seong Soo A; Lee, Kee Hyoung; Choung, Ji-Tae; Tockgo, Young Chang.

In: Microbiology and Immunology, Vol. 49, No. 6, 19.07.2005, p. 521-527.

Research output: Contribution to journalArticle

Lim, Chae Seung ; Yoon, Jae Kyun ; Chang, Eun Ah ; Suh, In Bum ; An, Seong Soo A ; Lee, Kee Hyoung ; Choung, Ji-Tae ; Tockgo, Young Chang. / Seroprevalence to the circumsporozoite protein peptide antigen of Plasmodium vivax in Korean children. In: Microbiology and Immunology. 2005 ; Vol. 49, No. 6. pp. 521-527.
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