Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women

B. T. Lee, Byung-Joo Ham

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. We investigated the possible relationship between several polymorphisms in the serotonin (5-HT) system and amygdala responses to negative facial stimuli in Korean women using functional magnetic resonance imaging. All participants were genotyped with regard to the following polymorphisms: the serotonin transporter-gene-linked polymorphic region (5-HTTLPR), tryptophan hydroxylase 2 (TPH2) G(-703)T, 5-HT1A C(-1019)G and 5-HT2A single nucleotide polymorphism (SNP) rs6311. We found increased activations in response to angry facial stimuli in the bilateral amygdala of subjects with the long allele of 5-HTTLPR compared with those with two copies of the short allele. Higher activations in response to sad facial stimuli were found in the bilateral amygdala of subjects with the T/T genotype of 5-HT2A SNP rs6311, compared with C allele carriers, and in subjects with the G/G genotype of TPH2 G(-703)T, compared with those with T/T and G/T genotypes. Our results for individuals from an Asian population countered a previous finding for a Caucasian population and identified the moderating role of genetic background in the relationships between these serotonergic gene polymorphisms and amygdala function elicited by negative emotional stimuli.

Original languageEnglish
Pages (from-to)899-905
Number of pages7
JournalGenes, Brain and Behavior
Volume7
Issue number8
DOIs
Publication statusPublished - 2008 Nov 1
Externally publishedYes

Fingerprint

Amygdala
Tryptophan Hydroxylase
Alleles
Genotype
Genes
Single Nucleotide Polymorphism
Serotonin
Serotonin Plasma Membrane Transport Proteins
Mood Disorders
Population
Alcoholism
Personality
Magnetic Resonance Imaging

Keywords

  • Amygdala
  • Emotion
  • Functional magnetic resonance imaging
  • Gene
  • Polymorphism
  • Serotonergic

ASJC Scopus subject areas

  • Genetics
  • Behavioral Neuroscience
  • Neurology

Cite this

Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. / Lee, B. T.; Ham, Byung-Joo.

In: Genes, Brain and Behavior, Vol. 7, No. 8, 01.11.2008, p. 899-905.

Research output: Contribution to journalArticle

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