Serotonergic genes and personality traits in the Korean population

Byung-Joo Ham, Yong Ho Kim, Myung Jin Choi, Ji Hyun Cha, Yun Kyeung Choi, Min-Soo Lee

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months. All participants were tested by the Temperament and Character Inventory (TCI) and genotyped serotonin transporter, serotonin receptors (5-HT 2A and 5-HT 6) and tryptophan hydroxylase gene polymorphisms. Genotyping was analyzed with polymerase chain reaction. Differences in TCI dimensions and sub-scales among three groups were examined with ANOVA. Our result suggested that 5-HT 2A receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence (ST). Our result also indicated a significant relationship between 5-HT 6 receptor gene polymorphism (C267T) and ST. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

Original languageEnglish
Pages (from-to)2-5
Number of pages4
JournalNeuroscience Letters
Volume354
Issue number1
DOIs
Publication statusPublished - 2004 Jan 2

Fingerprint

Personality
Population
Genes
Serotonin
Temperament
Tryptophan Hydroxylase
Receptor, Serotonin, 5-HT2A
Equipment and Supplies
Serotonin Plasma Membrane Transport Proteins
Serotonin Receptors
Mood Disorders
Alcoholism
Psychiatry
Analysis of Variance
Polymerase Chain Reaction

Keywords

  • Genetics
  • Personality traits
  • Polymorphism
  • Serotonin transporter
  • Serotonin-2A receptor
  • Serotonin-6 receptor
  • Tryptophan hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Serotonergic genes and personality traits in the Korean population. / Ham, Byung-Joo; Kim, Yong Ho; Choi, Myung Jin; Cha, Ji Hyun; Choi, Yun Kyeung; Lee, Min-Soo.

In: Neuroscience Letters, Vol. 354, No. 1, 02.01.2004, p. 2-5.

Research output: Contribution to journalArticle

Ham, Byung-Joo ; Kim, Yong Ho ; Choi, Myung Jin ; Cha, Ji Hyun ; Choi, Yun Kyeung ; Lee, Min-Soo. / Serotonergic genes and personality traits in the Korean population. In: Neuroscience Letters. 2004 ; Vol. 354, No. 1. pp. 2-5.
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