Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in korean patients with major depression

Yong Gu Kim, Hun Soo Chang, Eun Soo Won, Byung Joo Ham, Min Soo Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aims: The genetic variations in serotonin-related genes may be associated with antidepressant treatment response in major depressive disorder (MDD). The tryptophan hydroxylase-1 (TPH1) gene and serotonin 5A receptor (HTR5A) gene are known to be involved in serotonin biosynthesis and signal transduction, respectively. The purpose of this study was to investigate a possible interaction between the TPH1 gene and the HTR5A gene in the treatment outcome of escitalopram in MDD. Methods: In total, 245 patients diagnosed with MDD were recruited, and their symptoms were evaluated using the 17-item Hamilton Depression Rating scale (HAMD-17). The association between the TPH1 218A/C and HTR5A 12A/T polymorphisms and the clinical outcomes (remission, response and changes in HAMD-17 score) was investigated after 2, 4 and 8 weeks of escitalopram treatment using multiple logistic regression or multiple linear regression analysis. Results: No significant associations of TPH1 or HTR5A gene polymorphisms were observed with either response rate or remission rate at 2, 4 and 8 weeks after escitalopram treatment. In addition, the gene-gene interaction between TPH1 and HTR5A genes was not associated with the treatment outcome. Conclusions: Our results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression.

Original languageEnglish
Pages (from-to)210-219
Number of pages10
JournalNeuropsychobiology
Volume69
Issue number4
DOIs
Publication statusPublished - 2014 Jul

Keywords

  • Escitalopram treatment response
  • Major depressive disorder
  • Serotonin 5A receptor
  • Tryptophan hydroxylase-1

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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