Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatment

Min-Soo Lee, Hwa Young Lee, Heon-Jeong Lee, Seung Ho Ryu

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective: This study investigates the relationship between the serotonin transporter linked polymorphic region (5-HTTLPR) and the long-term outcome of antidepressant treatment. Methods: One hundred and twenty-eight patients with major depressive disorder were evaluated for long-term outcome (up to 3 years) of antidepressant treatment. The severity and improvement of depression were assessed with the Clinical Global Impression scale. The genotypes of 5-HTTLPR in the patients were determined using polymerase chain reaction. Results: During the long-term treatment of antidepressants (1-3 years of treatment), clinical improvement of depressive symptoms was more significant for carriers of the long (I) allele [I/I and I/short (s) genotypes] than for those possessing the s/s genotype (P=0.025 at 1 year, P=0.005 at 2 years, P=0.005 at 3 years). A response to treatment was also significantly more frequent in carriers of the I allele than in those with the s/s genotype (P=0.015). Conclusion: These findings show that patients with major depressive disorder possessing the 5-HTTLPR I allele may exhibit a better long-term outcome when treated with antidepressants.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalPsychiatric Genetics
Volume14
Issue number2
DOIs
Publication statusPublished - 2004 Jun 1

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Serotonin Plasma Membrane Transport Proteins
Antidepressive Agents
Genotype
Alleles
Major Depressive Disorder
Genes
Depression
Therapeutics
Polymerase Chain Reaction

Keywords

  • Long-term outcome
  • Major depressive disorder
  • Polymorphism
  • Serotonin transporter

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatment. / Lee, Min-Soo; Lee, Hwa Young; Lee, Heon-Jeong; Ryu, Seung Ho.

In: Psychiatric Genetics, Vol. 14, No. 2, 01.06.2004, p. 111-115.

Research output: Contribution to journalArticle

Lee, Min-Soo ; Lee, Hwa Young ; Lee, Heon-Jeong ; Ryu, Seung Ho. / Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatment. In: Psychiatric Genetics. 2004 ; Vol. 14, No. 2. pp. 111-115.
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