Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatment

Min Soo Lee, Hwa Young Lee, Heon Jeong Lee, Seung Ho Ryu

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


Objective: This study investigates the relationship between the serotonin transporter linked polymorphic region (5-HTTLPR) and the long-term outcome of antidepressant treatment. Methods: One hundred and twenty-eight patients with major depressive disorder were evaluated for long-term outcome (up to 3 years) of antidepressant treatment. The severity and improvement of depression were assessed with the Clinical Global Impression scale. The genotypes of 5-HTTLPR in the patients were determined using polymerase chain reaction. Results: During the long-term treatment of antidepressants (1-3 years of treatment), clinical improvement of depressive symptoms was more significant for carriers of the long (I) allele [I/I and I/short (s) genotypes] than for those possessing the s/s genotype (P=0.025 at 1 year, P=0.005 at 2 years, P=0.005 at 3 years). A response to treatment was also significantly more frequent in carriers of the I allele than in those with the s/s genotype (P=0.015). Conclusion: These findings show that patients with major depressive disorder possessing the 5-HTTLPR I allele may exhibit a better long-term outcome when treated with antidepressants.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalPsychiatric Genetics
Issue number2
Publication statusPublished - 2004 Jun


  • Long-term outcome
  • Major depressive disorder
  • Polymorphism
  • Serotonin transporter

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry


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