Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010

Eun Young Cho, Hyunju Lee, Eun Hwa Choi, Yae Jean Kim, Byung Wook Eun, Yong Kyun Cho, Yun Kyung Kim, Dae Sun Jo, Hye Soo Lee, Jina Lee, Mi Na Kim, Dong Soo Kim, Hoan Jong Lee

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Abstract

This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.

Original languageEnglish
Pages (from-to)481-486
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume78
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Conjugate Vaccines
Korea
Microbial Drug Resistance
Streptococcus pneumoniae
Infection
Pneumococcal Vaccines
Serogroup
Vaccination
Vaccines

Keywords

  • Antimicrobial resistance
  • Pneumococcal vaccines
  • Serotype
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010. / Cho, Eun Young; Lee, Hyunju; Choi, Eun Hwa; Kim, Yae Jean; Eun, Byung Wook; Cho, Yong Kyun; Kim, Yun Kyung; Jo, Dae Sun; Lee, Hye Soo; Lee, Jina; Kim, Mi Na; Kim, Dong Soo; Lee, Hoan Jong.

In: Diagnostic Microbiology and Infectious Disease, Vol. 78, No. 4, 01.01.2014, p. 481-486.

Research output: Contribution to journalArticle

Cho, Eun Young ; Lee, Hyunju ; Choi, Eun Hwa ; Kim, Yae Jean ; Eun, Byung Wook ; Cho, Yong Kyun ; Kim, Yun Kyung ; Jo, Dae Sun ; Lee, Hye Soo ; Lee, Jina ; Kim, Mi Na ; Kim, Dong Soo ; Lee, Hoan Jong. / Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010. In: Diagnostic Microbiology and Infectious Disease. 2014 ; Vol. 78, No. 4. pp. 481-486.
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abstract = "This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9{\%}), 19 F (12.1{\%}), and 6B (8.6{\%}). Between 2006 and 2010, PCV7 serotypes decreased from 62.5{\%} to 21.4{\%} (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8{\%} to 42.9{\%} (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2{\%} to 21.7{\%} (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4{\%} to 47.8{\%} (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.",
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