Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary

SOO JIN PARK, WHASUN LIM, JAEHEE MUN, HAERIN PAIK, SUNWOO PARK, HYUNJI LIM, JUNHWAN KIM, EUN JI LEE, GA WON YIM, NARA LEE, CHEOL LEE, JAE WEON KIM, GWONHWA SONG, HEE SEUNG KIM

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: To evaluate the role of serine protease inhibitor B11 (SERPINB11) expression as a prognostic biomarker in high-grade serous carcinoma (HGSC) and clear cell carcinoma of the ovary (CCC). Materials and Methods: We obtained tumor tissues from patients with HGSC (n=145) and CCC (n=59). We evaluated immunohistochemically the expression of SERPINB11 and investigated whether SERPINB11 expression affects platinum-resistance and the prognosis of HGSC and CCC. Results: High expression of SERPINB11 was more common in CCC than in HGSC (57.6% vs. 28.3%; p<0.01), and SEPRINB11 expression did not correlate with platinum-resistance of HGSC and CCC. High expression of SERPINB11 was associated with worse progression-free survival and overall survival with marginal significance in HGSC; no relation between SERPINB11 expression and the prognosis of CCC was found. Conclusion: SERPINB11 expression maybe a prognostic biomarker for HGSC.

Original languageEnglish
Pages (from-to)2647-2653
Number of pages7
JournalIn Vivo
Volume35
Issue number5
DOIs
Publication statusPublished - 2021 Oct

Keywords

  • Clear cell
  • High-grade serous
  • Ovarian cancer
  • Prognosis
  • SERPINB11

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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