Serum adipocyte fatty acid-binding protein is associated independently with vascular inflammation: Analysis with 18F-fluorodeoxyglucose positron emission tomography

Hye Jin Yoo, Sungeun Kim, Man Sik Park, Hae Yoon Choi, Sae Jeong Yang, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi, Kyung Mook Choi

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36 Citations (Scopus)


Context: The inflammatory status of atherosclerotic lesions is a major factor triggering acute cardiovascular events. Growing evidence has shown that adipocyte fatty acid-binding protein (A-FABP) has an important role in the development of atherosclerosis. Objective: The objective of the study was to determine the association between circulating A-FABP levels with vascular inflammation as measured using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET), which is a novel imaging technique for noninvasive measurement of atherosclerotic inflammation. Design: This was a cross-sectional study. Participants: Eighty-seven men without previously diagnosed cardiovascular disease or diabetes participated in the study. Main Outcome Measure: We measured the serum A-FABP, adiponectin, and leptin levels as well as other cardiovascular risk factors. Vascular inflammation in the carotid arterial wall, as indicated by the target to background ratio (TBR), was analyzed using FDG-PET. Results: The circulating A-FABP and leptin levels had positive correlations with maximum TBR values (r=0.38, P<0.001; and r=0.28, P=0.010, respectively), whereas the adiponectin levels had a negative correlation (r = -0.31, P = 0.004). The maximum TBR levels exhibited an additive linear increment according to the rise in tertiles of the A-FABP levels in subjects with and without metabolic syndrome. Multiple regression analysis showed that serum A-FABP levels were independently associated with maximum TBR after adjustment for other cardiovascular risk factors (P = 0.006). Conclusions: Circulating A-FABP, adiponectin, and leptin levels were shown to be associated with vascular inflammation, as measured using FDG-PET. Specifically, the A-FABP level was an independent risk factor for vascular inflammation in Korean men without cardiovascular disease or diabetes.

Original languageEnglish
Pages (from-to)E488-E492
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
Publication statusPublished - 2011 Mar

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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