Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys

A 3-y prospective cohort study

Kyung Mook Choi, Mary Yannakoulia, Min S. Park, Geum-Joon Cho, Jung H. Kim, Seung H. Lee, Taik G. Hwang, Sei J. Yang, Tai N. Kim, Hye-Jin Yoo, Sei-Hyun Baik, Seon Mee Kim, Christos S. Mantzoros

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Adipocyte fatty acid-binding protein (A-FABP), retinol-binding protein 4 (RBP4), and adiponectin have been associated with insulin resistance and the metabolic syndrome in adults. Objective: We evaluated the association of A-FABP, RBP4, and adiponectin with the metabolic syndrome in Korean boys. Design: In this prospective cohort study, 159 boys participated in a school-based health examination and were followed up after 3 y. The metabolic syndrome in children was defined by using the pediatric adaptation of the National Cholesterol Education Program criteria. Results: Compared with normal-weight participants, overweight children had significantly higher A-FABP (23.6 ± 8.2 compared with 12.8 ± 5.1 μg/L, P < 0.001) and RBP4 (69.3 ± 17.1 compared with 59.7 ± 15.3 μg/mL, P = 0.001) concentrations and significantly lower adiponectin concentrations (11.5 ± 5.4 compared with 18.1 ± 8.4 μg/mL, P < 0.001). Baseline A-FABP concentrations were significantly higher in children who developed the metabolic syndrome than in those who did not, whereas adiponectin concentrations were significantly lower. Baseline RBP4 concentrations were not significantly different between the 2 groups. Multiple logistic regression analysis showed that only A-FABP was an independent predictor of the development of the metabolic syndrome after adjustment for Tanner stage, insulin resistance, body mass index, sleep duration, and physical activity (odds ratio: 17.3; 95% CI: 1.25, 239.76; highest compared with lowest tertile), whereas the significant association between adiponectin and the metabolic syndrome observed by using bivariate analysis reflects, in part, an underlying association with obesity. Conclusion: A-FABP predicts the development of the metabolic syndrome independently of pubertal status, adiposity, and insulin resistance in Korean boys.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume93
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

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Retinol-Binding Proteins
Fatty Acid-Binding Proteins
Adiponectin
Adipocytes
Protein Binding
Cohort Studies
Prospective Studies
Serum
Insulin Resistance
School Health Services
Adiposity
Sleep
Body Mass Index
Obesity
Logistic Models
Odds Ratio
Cholesterol
Regression Analysis
Exercise
Pediatrics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys : A 3-y prospective cohort study. / Choi, Kyung Mook; Yannakoulia, Mary; Park, Min S.; Cho, Geum-Joon; Kim, Jung H.; Lee, Seung H.; Hwang, Taik G.; Yang, Sei J.; Kim, Tai N.; Yoo, Hye-Jin; Baik, Sei-Hyun; Kim, Seon Mee; Mantzoros, Christos S.

In: American Journal of Clinical Nutrition, Vol. 93, No. 1, 01.01.2011, p. 19-26.

Research output: Contribution to journalArticle

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abstract = "Background: Adipocyte fatty acid-binding protein (A-FABP), retinol-binding protein 4 (RBP4), and adiponectin have been associated with insulin resistance and the metabolic syndrome in adults. Objective: We evaluated the association of A-FABP, RBP4, and adiponectin with the metabolic syndrome in Korean boys. Design: In this prospective cohort study, 159 boys participated in a school-based health examination and were followed up after 3 y. The metabolic syndrome in children was defined by using the pediatric adaptation of the National Cholesterol Education Program criteria. Results: Compared with normal-weight participants, overweight children had significantly higher A-FABP (23.6 ± 8.2 compared with 12.8 ± 5.1 μg/L, P < 0.001) and RBP4 (69.3 ± 17.1 compared with 59.7 ± 15.3 μg/mL, P = 0.001) concentrations and significantly lower adiponectin concentrations (11.5 ± 5.4 compared with 18.1 ± 8.4 μg/mL, P < 0.001). Baseline A-FABP concentrations were significantly higher in children who developed the metabolic syndrome than in those who did not, whereas adiponectin concentrations were significantly lower. Baseline RBP4 concentrations were not significantly different between the 2 groups. Multiple logistic regression analysis showed that only A-FABP was an independent predictor of the development of the metabolic syndrome after adjustment for Tanner stage, insulin resistance, body mass index, sleep duration, and physical activity (odds ratio: 17.3; 95{\%} CI: 1.25, 239.76; highest compared with lowest tertile), whereas the significant association between adiponectin and the metabolic syndrome observed by using bivariate analysis reflects, in part, an underlying association with obesity. Conclusion: A-FABP predicts the development of the metabolic syndrome independently of pubertal status, adiposity, and insulin resistance in Korean boys.",
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T2 - A 3-y prospective cohort study

AU - Choi, Kyung Mook

AU - Yannakoulia, Mary

AU - Park, Min S.

AU - Cho, Geum-Joon

AU - Kim, Jung H.

AU - Lee, Seung H.

AU - Hwang, Taik G.

AU - Yang, Sei J.

AU - Kim, Tai N.

AU - Yoo, Hye-Jin

AU - Baik, Sei-Hyun

AU - Kim, Seon Mee

AU - Mantzoros, Christos S.

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