Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome

Kyung Mook Choi, O. H. Ryu, K. W. Lee, H. Y. Kim, Ji A Seo, Sin Gon Kim, Nan Hee Kim, D. S. Choi, Sei-Hyun Baik

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

We examined the association between interleukin-10 (IL-10), adiponectin levels and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP). Furthermore, the association of these anti-/pro-inflammatory cytokine levels with the metabolic syndrome was investigated. The study subjects were composed of 312 Korean individuals without diabetes. Serum adiponectin level was associated with hsCRP (r = -0.21, P < 0.001), IL-6 (r = -0.13, P < 0.05) and IL-10 (r = -0.22, P < 0.001) levels. Subjects without the metabolic syndrome showed higher adiponectin (17.03 μg/ml versus 13.85 μg/ml, P < 0.001) and IL-10 (4.74 pg/ml versus 4.34 pg/ml, P = 0.014) levels, and lower serum hsCRP (0.38 μg/ml versus 0.66 μg/ml, P = 0.001) and IL-6 (0.94 pg/ml versus 1.32 pg/ml, P = 0.009) levels compared to those with the metabolic syndrome. In multiple logistic regression analysis, the metabolic syndrome was associated with sex, age, waist circumference, systolic blood pressure, HDL cholesterol, triglyceride, fasting blood glucose and interleukin-10. Furthermore, serum adiponectin levels are associated with serum hsCRP, IL-6 and IL-10 levels. These results suggest that adiponectin might be associated with the metabolic syndrome through regulation of pro-/anti-inflammatory cytokines.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume75
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

Fingerprint

Adiponectin
Interleukin-10
C-Reactive Protein
Interleukin-6
Serum
Anti-Inflammatory Agents
Cytokines
Blood Pressure
Waist Circumference
HDL Cholesterol
Blood Glucose
Fasting
Triglycerides
Logistic Models
Regression Analysis

Keywords

  • Adiponectin
  • C-reactive protein
  • Interleukin-10
  • Interleukin-6
  • Metabolic syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome. / Choi, Kyung Mook; Ryu, O. H.; Lee, K. W.; Kim, H. Y.; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Choi, D. S.; Baik, Sei-Hyun.

In: Diabetes Research and Clinical Practice, Vol. 75, No. 2, 01.02.2007, p. 235-240.

Research output: Contribution to journalArticle

@article{f82d9f357cef4bcfbe8eb0d4785ba6d5,
title = "Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome",
abstract = "We examined the association between interleukin-10 (IL-10), adiponectin levels and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP). Furthermore, the association of these anti-/pro-inflammatory cytokine levels with the metabolic syndrome was investigated. The study subjects were composed of 312 Korean individuals without diabetes. Serum adiponectin level was associated with hsCRP (r = -0.21, P < 0.001), IL-6 (r = -0.13, P < 0.05) and IL-10 (r = -0.22, P < 0.001) levels. Subjects without the metabolic syndrome showed higher adiponectin (17.03 μg/ml versus 13.85 μg/ml, P < 0.001) and IL-10 (4.74 pg/ml versus 4.34 pg/ml, P = 0.014) levels, and lower serum hsCRP (0.38 μg/ml versus 0.66 μg/ml, P = 0.001) and IL-6 (0.94 pg/ml versus 1.32 pg/ml, P = 0.009) levels compared to those with the metabolic syndrome. In multiple logistic regression analysis, the metabolic syndrome was associated with sex, age, waist circumference, systolic blood pressure, HDL cholesterol, triglyceride, fasting blood glucose and interleukin-10. Furthermore, serum adiponectin levels are associated with serum hsCRP, IL-6 and IL-10 levels. These results suggest that adiponectin might be associated with the metabolic syndrome through regulation of pro-/anti-inflammatory cytokines.",
keywords = "Adiponectin, C-reactive protein, Interleukin-10, Interleukin-6, Metabolic syndrome",
author = "Choi, {Kyung Mook} and Ryu, {O. H.} and Lee, {K. W.} and Kim, {H. Y.} and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Choi, {D. S.} and Sei-Hyun Baik",
year = "2007",
month = "2",
day = "1",
doi = "10.1016/j.diabres.2006.06.019",
language = "English",
volume = "75",
pages = "235--240",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome

AU - Choi, Kyung Mook

AU - Ryu, O. H.

AU - Lee, K. W.

AU - Kim, H. Y.

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Choi, D. S.

AU - Baik, Sei-Hyun

PY - 2007/2/1

Y1 - 2007/2/1

N2 - We examined the association between interleukin-10 (IL-10), adiponectin levels and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP). Furthermore, the association of these anti-/pro-inflammatory cytokine levels with the metabolic syndrome was investigated. The study subjects were composed of 312 Korean individuals without diabetes. Serum adiponectin level was associated with hsCRP (r = -0.21, P < 0.001), IL-6 (r = -0.13, P < 0.05) and IL-10 (r = -0.22, P < 0.001) levels. Subjects without the metabolic syndrome showed higher adiponectin (17.03 μg/ml versus 13.85 μg/ml, P < 0.001) and IL-10 (4.74 pg/ml versus 4.34 pg/ml, P = 0.014) levels, and lower serum hsCRP (0.38 μg/ml versus 0.66 μg/ml, P = 0.001) and IL-6 (0.94 pg/ml versus 1.32 pg/ml, P = 0.009) levels compared to those with the metabolic syndrome. In multiple logistic regression analysis, the metabolic syndrome was associated with sex, age, waist circumference, systolic blood pressure, HDL cholesterol, triglyceride, fasting blood glucose and interleukin-10. Furthermore, serum adiponectin levels are associated with serum hsCRP, IL-6 and IL-10 levels. These results suggest that adiponectin might be associated with the metabolic syndrome through regulation of pro-/anti-inflammatory cytokines.

AB - We examined the association between interleukin-10 (IL-10), adiponectin levels and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP). Furthermore, the association of these anti-/pro-inflammatory cytokine levels with the metabolic syndrome was investigated. The study subjects were composed of 312 Korean individuals without diabetes. Serum adiponectin level was associated with hsCRP (r = -0.21, P < 0.001), IL-6 (r = -0.13, P < 0.05) and IL-10 (r = -0.22, P < 0.001) levels. Subjects without the metabolic syndrome showed higher adiponectin (17.03 μg/ml versus 13.85 μg/ml, P < 0.001) and IL-10 (4.74 pg/ml versus 4.34 pg/ml, P = 0.014) levels, and lower serum hsCRP (0.38 μg/ml versus 0.66 μg/ml, P = 0.001) and IL-6 (0.94 pg/ml versus 1.32 pg/ml, P = 0.009) levels compared to those with the metabolic syndrome. In multiple logistic regression analysis, the metabolic syndrome was associated with sex, age, waist circumference, systolic blood pressure, HDL cholesterol, triglyceride, fasting blood glucose and interleukin-10. Furthermore, serum adiponectin levels are associated with serum hsCRP, IL-6 and IL-10 levels. These results suggest that adiponectin might be associated with the metabolic syndrome through regulation of pro-/anti-inflammatory cytokines.

KW - Adiponectin

KW - C-reactive protein

KW - Interleukin-10

KW - Interleukin-6

KW - Metabolic syndrome

UR - http://www.scopus.com/inward/record.url?scp=33845447909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845447909&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2006.06.019

DO - 10.1016/j.diabres.2006.06.019

M3 - Article

C2 - 16872712

AN - SCOPUS:33845447909

VL - 75

SP - 235

EP - 240

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 2

ER -