Serum aminotransferase levels instead of etiology affects the accuracy of transient elastography in chronic viral hepatitis patients

Hye Jin Cho, Yeon Seok Seo, Kwang Gyun Lee, Jong Jin Hyun, Hyonggin An, Bora Keum, Ji Hoon Kim, Hyung Joon Yim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    Background and Aim: It is still uncertain whether the accuracy of transient elastography (TE) in predicting the fibrosis stage is similar in chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The present study was carried out to evaluate whether the underlying cause of chronic viral hepatitis affects the predictive accuracy of TE. Methods: Patients with CHB or CHC who were admitted for a liver biopsy were enrolled. Patients underwent TE and laboratory tests on the same day as the liver biopsy. The predictive accuracy was analyzed by comparing the areas under the receiver-operating characteristic curves (AUCs). Results: Two-hundred and seven patients were enrolled, comprising 121 CHB patients and 86 CHC patients). The patients were aged 44±14 years, and 121 (58.5%) of them were men. AUCs for predicting significant fibrosis were significantly lower in CHB patients than in CHC patients (P=0.043). The serum alanine aminotransferase (ALT) level was associated with overestimation and underestimation of the fibrosis stage, while the cause of chronic hepatitis was not. AUCs for predicting significant fibrosis were significantly lower in patients with ALT levels >70IU/L (AUC, 0.830; 95% CI, 0.742-0.898) than in patients with ALT levels ≤70IU/L (0.944; 0.882-0.979; P=0.015). Conclusions: Although the predictive accuracy of TE in predicting significant fibrosis differed significantly with the cause of chronic hepatitis, this difference was due to the degree of serum ALT levels rather than to the cause of hepatitis itself. Avoiding performing TE in patients with elevated ALT levels is recommended to guarantee the predictive accuracy of TE.

    Original languageEnglish
    Pages (from-to)492-500
    Number of pages9
    JournalJournal of Gastroenterology and Hepatology (Australia)
    Volume26
    Issue number3
    DOIs
    Publication statusPublished - 2011 Mar

    Keywords

    • Alanine aminotransferase
    • FibroScan
    • Liver stiffness
    • Necroinflammation

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

    Fingerprint

    Dive into the research topics of 'Serum aminotransferase levels instead of etiology affects the accuracy of transient elastography in chronic viral hepatitis patients'. Together they form a unique fingerprint.

    Cite this