Serum anti-amyloid-β antibodies and Alzheimer's disease in elderly Korean patients

M. S. Song, I. Mook-Jung, H. J. Lee, J. Y. Min, Moon Ho Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-β (Aβ) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Aβ antibodies from the serum of 153 patients with AD using an enzymelinked immunosorbent assay method. The levels of anti-Aβ antibody from patients in the control group (n = 193) were compared with those of patients with AD. Our results showed a significantly lower anti-Aβ antibody level in patients with AD than in the control group. These results showed that the anti-Aβ antibody level in serum could potentially be used to diagnose the presence of AD.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalJournal of International Medical Research
Volume35
Issue number3
Publication statusPublished - 2007 May 1

Fingerprint

Amyloid
Anti-Idiotypic Antibodies
Alzheimer Disease
Antibodies
Serum
Amyloid Plaques
Immunosorbents
Control Groups
Neurofibrillary Tangles
Magnetic resonance
Assays
Brain
Magnetic Resonance Imaging
Imaging techniques
Peptides

Keywords

  • Alzheimer's disease
  • Diagnostic marker
  • Elderly patients
  • Serum anti-amyloid-beta antibody

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Serum anti-amyloid-β antibodies and Alzheimer's disease in elderly Korean patients. / Song, M. S.; Mook-Jung, I.; Lee, H. J.; Min, J. Y.; Park, Moon Ho.

In: Journal of International Medical Research, Vol. 35, No. 3, 01.05.2007, p. 301-306.

Research output: Contribution to journalArticle

Song, M. S. ; Mook-Jung, I. ; Lee, H. J. ; Min, J. Y. ; Park, Moon Ho. / Serum anti-amyloid-β antibodies and Alzheimer's disease in elderly Korean patients. In: Journal of International Medical Research. 2007 ; Vol. 35, No. 3. pp. 301-306.
@article{f5254e9e0f0b4f2fb3ee3c908489d826,
title = "Serum anti-amyloid-β antibodies and Alzheimer's disease in elderly Korean patients",
abstract = "Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-β (Aβ) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Aβ antibodies from the serum of 153 patients with AD using an enzymelinked immunosorbent assay method. The levels of anti-Aβ antibody from patients in the control group (n = 193) were compared with those of patients with AD. Our results showed a significantly lower anti-Aβ antibody level in patients with AD than in the control group. These results showed that the anti-Aβ antibody level in serum could potentially be used to diagnose the presence of AD.",
keywords = "Alzheimer's disease, Diagnostic marker, Elderly patients, Serum anti-amyloid-beta antibody",
author = "Song, {M. S.} and I. Mook-Jung and Lee, {H. J.} and Min, {J. Y.} and Park, {Moon Ho}",
year = "2007",
month = "5",
day = "1",
language = "English",
volume = "35",
pages = "301--306",
journal = "Journal of International Medical Research",
issn = "0300-0605",
publisher = "Field House Publishing LLP",
number = "3",

}

TY - JOUR

T1 - Serum anti-amyloid-β antibodies and Alzheimer's disease in elderly Korean patients

AU - Song, M. S.

AU - Mook-Jung, I.

AU - Lee, H. J.

AU - Min, J. Y.

AU - Park, Moon Ho

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-β (Aβ) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Aβ antibodies from the serum of 153 patients with AD using an enzymelinked immunosorbent assay method. The levels of anti-Aβ antibody from patients in the control group (n = 193) were compared with those of patients with AD. Our results showed a significantly lower anti-Aβ antibody level in patients with AD than in the control group. These results showed that the anti-Aβ antibody level in serum could potentially be used to diagnose the presence of AD.

AB - Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-β (Aβ) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Aβ antibodies from the serum of 153 patients with AD using an enzymelinked immunosorbent assay method. The levels of anti-Aβ antibody from patients in the control group (n = 193) were compared with those of patients with AD. Our results showed a significantly lower anti-Aβ antibody level in patients with AD than in the control group. These results showed that the anti-Aβ antibody level in serum could potentially be used to diagnose the presence of AD.

KW - Alzheimer's disease

KW - Diagnostic marker

KW - Elderly patients

KW - Serum anti-amyloid-beta antibody

UR - http://www.scopus.com/inward/record.url?scp=34250809074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250809074&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 301

EP - 306

JO - Journal of International Medical Research

JF - Journal of International Medical Research

SN - 0300-0605

IS - 3

ER -