Serum anti-amyloid-β antibodies and Alzheimer's disease in elderly Korean patients

M. S. Song, I. Mook-Jung, H. J. Lee, J. Y. Min, Muno H. Park

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-β (Aβ) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Aβ antibodies from the serum of 153 patients with AD using an enzymelinked immunosorbent assay method. The levels of anti-Aβ antibody from patients in the control group (n = 193) were compared with those of patients with AD. Our results showed a significantly lower anti-Aβ antibody level in patients with AD than in the control group. These results showed that the anti-Aβ antibody level in serum could potentially be used to diagnose the presence of AD.

    Original languageEnglish
    Pages (from-to)301-306
    Number of pages6
    JournalJournal of International Medical Research
    Volume35
    Issue number3
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Alzheimer's disease
    • Diagnostic marker
    • Elderly patients
    • Serum anti-amyloid-beta antibody

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Biochemistry, medical

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