Abstract
Few studies have investigated the long-term effects of gonadotropin-releasing hormone (GnRH) agonist treatment on the reproductive function of central precocious puberty (CPP) girls. In this cross-sectional study, we assessed the ovarian function by analyzing the serum anti-Müllerian hormone (AMH) levels of CPP girls. Our study included 505 CPP girls subdivided into 5 groups according to the GnRH agonist treatment stage: group A (before treatment, n = 98), group B (3 months after initiation, n = 103), group C (12 months after initiation, n = 101), group D (24 months after initiation, n = 101), and group E (6 months after discontinuation, n = 102). We compared the serum AMH levels of the CPP girls with those of 100 bone age-matched controls (before treatment: n = 55; after discontinuation: n = 45). At baseline, the mean AMH level of the CPP girls was 5.9 ± 3.6 ng/mL. The mean AMH level after 3 months of the GnRH agonist treatment was lower (4.7 ± 3.2 ng/mL, P = 0.047) than that at baseline and recovered after 12 months of treatment. Six months after discontinuation, the AMH levels were similar to those at pre-treatment. Before and after the GnRH agonist treatment, the AMH levels were similar to those of the bone agematched controls. In the precocious puberty girls, the AMH levels based on the GnRH agonist treatment stage were all within the normal reference range. The results of this study suggest that GnRH agonist treatment has no adverse effects on the reproductive function.
| Original language | English |
|---|---|
| Pages (from-to) | 475-479 |
| Number of pages | 5 |
| Journal | Journal of Korean Medical Science |
| Volume | 32 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
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Keywords
- Anti-Müllerian hormone
- Gonadotropin-releasing hormone agonist
- Ovarian reserve
- Precocious
- Puberty
ASJC Scopus subject areas
- Medicine(all)
Cite this
Serum anti-Müllerian hormone levels in precocious puberty girls according to stage of GnRH agonist treatment. / Nam, Hyo-Kyoung; Kim, Hye Ryun; Rhie, Young-Jun; Lee, Kee Hyoung.
In: Journal of Korean Medical Science, Vol. 32, No. 3, 01.01.2017, p. 475-479.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum anti-Müllerian hormone levels in precocious puberty girls according to stage of GnRH agonist treatment
AU - Nam, Hyo-Kyoung
AU - Kim, Hye Ryun
AU - Rhie, Young-Jun
AU - Lee, Kee Hyoung
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Few studies have investigated the long-term effects of gonadotropin-releasing hormone (GnRH) agonist treatment on the reproductive function of central precocious puberty (CPP) girls. In this cross-sectional study, we assessed the ovarian function by analyzing the serum anti-Müllerian hormone (AMH) levels of CPP girls. Our study included 505 CPP girls subdivided into 5 groups according to the GnRH agonist treatment stage: group A (before treatment, n = 98), group B (3 months after initiation, n = 103), group C (12 months after initiation, n = 101), group D (24 months after initiation, n = 101), and group E (6 months after discontinuation, n = 102). We compared the serum AMH levels of the CPP girls with those of 100 bone age-matched controls (before treatment: n = 55; after discontinuation: n = 45). At baseline, the mean AMH level of the CPP girls was 5.9 ± 3.6 ng/mL. The mean AMH level after 3 months of the GnRH agonist treatment was lower (4.7 ± 3.2 ng/mL, P = 0.047) than that at baseline and recovered after 12 months of treatment. Six months after discontinuation, the AMH levels were similar to those at pre-treatment. Before and after the GnRH agonist treatment, the AMH levels were similar to those of the bone agematched controls. In the precocious puberty girls, the AMH levels based on the GnRH agonist treatment stage were all within the normal reference range. The results of this study suggest that GnRH agonist treatment has no adverse effects on the reproductive function.
AB - Few studies have investigated the long-term effects of gonadotropin-releasing hormone (GnRH) agonist treatment on the reproductive function of central precocious puberty (CPP) girls. In this cross-sectional study, we assessed the ovarian function by analyzing the serum anti-Müllerian hormone (AMH) levels of CPP girls. Our study included 505 CPP girls subdivided into 5 groups according to the GnRH agonist treatment stage: group A (before treatment, n = 98), group B (3 months after initiation, n = 103), group C (12 months after initiation, n = 101), group D (24 months after initiation, n = 101), and group E (6 months after discontinuation, n = 102). We compared the serum AMH levels of the CPP girls with those of 100 bone age-matched controls (before treatment: n = 55; after discontinuation: n = 45). At baseline, the mean AMH level of the CPP girls was 5.9 ± 3.6 ng/mL. The mean AMH level after 3 months of the GnRH agonist treatment was lower (4.7 ± 3.2 ng/mL, P = 0.047) than that at baseline and recovered after 12 months of treatment. Six months after discontinuation, the AMH levels were similar to those at pre-treatment. Before and after the GnRH agonist treatment, the AMH levels were similar to those of the bone agematched controls. In the precocious puberty girls, the AMH levels based on the GnRH agonist treatment stage were all within the normal reference range. The results of this study suggest that GnRH agonist treatment has no adverse effects on the reproductive function.
KW - Anti-Müllerian hormone
KW - Gonadotropin-releasing hormone agonist
KW - Ovarian reserve
KW - Precocious
KW - Puberty
UR - http://www.scopus.com/inward/record.url?scp=85013897743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013897743&partnerID=8YFLogxK
U2 - 10.3346/jkms.2017.32.3.475
DO - 10.3346/jkms.2017.32.3.475
M3 - Article
C2 - 28145651
AN - SCOPUS:85013897743
VL - 32
SP - 475
EP - 479
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 3
ER -