Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis

A multicentre study in Korea

Gheun Ho Kim, Bum Soon Choi, Dae-Ryong Cha, Dong Hyun Chee, Eunah Hwang, Hyung Wook Kim, Jae Hyun Chang, Joong Kyung Kim, Jung Woo Noh, Kwon Wook Joo, Sang Choel Lee, Sang Woong Han, Sejoong Kim, Soo Wan Kim, Sug Kyun Shin, Wondo Park, Won Kim, Wooseong Huh, Young-Joo Kwon, Young Sun Kang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients. Methods Data were collected from a total of 1,018 patients undergoing MHD without intercurrent illness, in 17 hemodialysis centers throughout the country. Serum levels of Ca, P, and intact parathyroid hormone (iPTH) were measured over 1 year, and the average values were retrospectively analyzed. Results Serum levels of Ca, P, and the Ca×P product were 9.1±0.7 mg/dL, 5.3±1.4 mg/dL, and 48.0±13.6 mg 2/dL2, respectively. However, the percentages of patients with Ca, P, and Ca × P product levels within the KDOQI guideline ranges were 58.7%, 51.0%, and 70.7%, respectively. Of the 1,018 patients, 270 (26.5%) had iPTH >300 pg/mL (uncontrolled SHPT), whereas 435 patients (42.7%) showed iPTH <150 pg/mL. Patients with uncontrolled SHPT had significantly higher values of serum Ca, P, and Ca×P product than those with iPTH >300 pg/mL. Conclusion Despite the current clinical practice guidelines, SHPT seems to be inadequately controlled in many MHD patients. Uncontrolled SHPT was associated with higher levels of serum Ca, P, and Ca < P product, suggestive of the importance of SHPT management.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalKidney Research and Clinical Practice
Volume33
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Korea
Phosphorus
Multicenter Studies
Renal Dialysis
Secondary Hyperparathyroidism
Maintenance
Calcium
Serum
Parathyroid Hormone
Kidney Diseases
Practice Guidelines
Guidelines
Minerals
Bone and Bones

Keywords

  • Calcium
  • Hemodialysis
  • Intact parathyroid hormone
  • Phosphorus
  • Secondary hyperparathyroidism

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis : A multicentre study in Korea. / Kim, Gheun Ho; Choi, Bum Soon; Cha, Dae-Ryong; Chee, Dong Hyun; Hwang, Eunah; Kim, Hyung Wook; Chang, Jae Hyun; Kim, Joong Kyung; Noh, Jung Woo; Joo, Kwon Wook; Lee, Sang Choel; Han, Sang Woong; Kim, Sejoong; Kim, Soo Wan; Shin, Sug Kyun; Park, Wondo; Kim, Won; Huh, Wooseong; Kwon, Young-Joo; Kang, Young Sun.

In: Kidney Research and Clinical Practice, Vol. 33, No. 1, 01.01.2014, p. 52-57.

Research output: Contribution to journalArticle

Kim, GH, Choi, BS, Cha, D-R, Chee, DH, Hwang, E, Kim, HW, Chang, JH, Kim, JK, Noh, JW, Joo, KW, Lee, SC, Han, SW, Kim, S, Kim, SW, Shin, SK, Park, W, Kim, W, Huh, W, Kwon, Y-J & Kang, YS 2014, 'Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis: A multicentre study in Korea', Kidney Research and Clinical Practice, vol. 33, no. 1, pp. 52-57. https://doi.org/10.1016/j.krcp.2013.12.003
Kim, Gheun Ho ; Choi, Bum Soon ; Cha, Dae-Ryong ; Chee, Dong Hyun ; Hwang, Eunah ; Kim, Hyung Wook ; Chang, Jae Hyun ; Kim, Joong Kyung ; Noh, Jung Woo ; Joo, Kwon Wook ; Lee, Sang Choel ; Han, Sang Woong ; Kim, Sejoong ; Kim, Soo Wan ; Shin, Sug Kyun ; Park, Wondo ; Kim, Won ; Huh, Wooseong ; Kwon, Young-Joo ; Kang, Young Sun. / Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis : A multicentre study in Korea. In: Kidney Research and Clinical Practice. 2014 ; Vol. 33, No. 1. pp. 52-57.
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T1 - Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis

T2 - A multicentre study in Korea

AU - Kim, Gheun Ho

AU - Choi, Bum Soon

AU - Cha, Dae-Ryong

AU - Chee, Dong Hyun

AU - Hwang, Eunah

AU - Kim, Hyung Wook

AU - Chang, Jae Hyun

AU - Kim, Joong Kyung

AU - Noh, Jung Woo

AU - Joo, Kwon Wook

AU - Lee, Sang Choel

AU - Han, Sang Woong

AU - Kim, Sejoong

AU - Kim, Soo Wan

AU - Shin, Sug Kyun

AU - Park, Wondo

AU - Kim, Won

AU - Huh, Wooseong

AU - Kwon, Young-Joo

AU - Kang, Young Sun

PY - 2014/1/1

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N2 - Background In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients. Methods Data were collected from a total of 1,018 patients undergoing MHD without intercurrent illness, in 17 hemodialysis centers throughout the country. Serum levels of Ca, P, and intact parathyroid hormone (iPTH) were measured over 1 year, and the average values were retrospectively analyzed. Results Serum levels of Ca, P, and the Ca×P product were 9.1±0.7 mg/dL, 5.3±1.4 mg/dL, and 48.0±13.6 mg 2/dL2, respectively. However, the percentages of patients with Ca, P, and Ca × P product levels within the KDOQI guideline ranges were 58.7%, 51.0%, and 70.7%, respectively. Of the 1,018 patients, 270 (26.5%) had iPTH >300 pg/mL (uncontrolled SHPT), whereas 435 patients (42.7%) showed iPTH <150 pg/mL. Patients with uncontrolled SHPT had significantly higher values of serum Ca, P, and Ca×P product than those with iPTH >300 pg/mL. Conclusion Despite the current clinical practice guidelines, SHPT seems to be inadequately controlled in many MHD patients. Uncontrolled SHPT was associated with higher levels of serum Ca, P, and Ca < P product, suggestive of the importance of SHPT management.

AB - Background In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients. Methods Data were collected from a total of 1,018 patients undergoing MHD without intercurrent illness, in 17 hemodialysis centers throughout the country. Serum levels of Ca, P, and intact parathyroid hormone (iPTH) were measured over 1 year, and the average values were retrospectively analyzed. Results Serum levels of Ca, P, and the Ca×P product were 9.1±0.7 mg/dL, 5.3±1.4 mg/dL, and 48.0±13.6 mg 2/dL2, respectively. However, the percentages of patients with Ca, P, and Ca × P product levels within the KDOQI guideline ranges were 58.7%, 51.0%, and 70.7%, respectively. Of the 1,018 patients, 270 (26.5%) had iPTH >300 pg/mL (uncontrolled SHPT), whereas 435 patients (42.7%) showed iPTH <150 pg/mL. Patients with uncontrolled SHPT had significantly higher values of serum Ca, P, and Ca×P product than those with iPTH >300 pg/mL. Conclusion Despite the current clinical practice guidelines, SHPT seems to be inadequately controlled in many MHD patients. Uncontrolled SHPT was associated with higher levels of serum Ca, P, and Ca < P product, suggestive of the importance of SHPT management.

KW - Calcium

KW - Hemodialysis

KW - Intact parathyroid hormone

KW - Phosphorus

KW - Secondary hyperparathyroidism

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