Serum creatine kinase in patients with rheumatic diseases

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Serum creatine kinase (CK) activity is reduced in some conditions, including rheumatic diseases, but the aetiology and significance remain to be clarified. The aim of this study was to investigate relationships between serum CK activity and other muscle enzymes, muscle mass, renal function, steroid use and disease activity in patients with rheumatic diseases. Serum CK activity was measured in sera from 498 patients with rheumatic diseases: rheumatoid arthritis (RA, n = 145), systemic lupus erythematosus (SLE n = 31), spondyloarthropathies (SPA, n = 35), polya thralgia/arthritis (Poly, n = 74), miscellaneous group (MI, n = 46), and in non-inflammaroty arthropathies (NIA, n = 167) as controls. Serum CK level was significantly reduced in RA (45.4 ± 1.9 IU/1), SLE (46.4 ± 4.2 IU/1), SpA (64.7 ± 5.6 IU/1) and MI (63.4 ± 4.8 IU/1), but not in poly (70.2 ± 3.1 IU/1), computed to controls (78.9 ± 2.4 IU/1) (P < 0.05). CK values correlated with aspartate aminotransferase (AST), erythrocyte sedimentation rate (ESR), body mass index (BMI and platelets (Plat) in RA; ESR and haemoglobin (Hb) in SLE, AST, ESR and Hb in SpA; lactate dehydrogenase (LDH), AST, ESR and Hb in Poly; LDH, AST, ESR, Hb and Ccr in MI; and LDH, AST and ESR in controls. In all patients with rheumatic diseases CK level was significantly corrrelated with LDH, AST, alanine aminotransferase (ALT), ESR, C-reactive protein (CRP) and BMI and prednisolone dose, but not with Ccr, age and disease duration. In conclusion, our data support the possibility that reduced CK activity is inversely correlated with inflammatory activity and correlated with other muscle enzymes, muscle mass and steroid use, but not with renal function, age and disease duration in rheumatic diseases.

Original languageEnglish
Pages (from-to)296-300
Number of pages5
JournalClinical Rheumatology
Volume19
Issue number4
Publication statusPublished - 2000 Aug 21

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Blood Sedimentation
Creatine Kinase
Rheumatic Diseases
Aspartate Aminotransferases
L-Lactate Dehydrogenase
Serum
Hemoglobins
Muscles
Steroids
Kidney
Spondylarthropathies
Joint Diseases
Enzymes
Prednisolone
Alanine Transaminase
Systemic Lupus Erythematosus
C-Reactive Protein
Arthritis
Rheumatoid Arthritis
Body Mass Index

Keywords

  • Creatine kinase
  • Rheumatic diseases

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Serum creatine kinase in patients with rheumatic diseases. / Lee, Young Ho; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.

In: Clinical Rheumatology, Vol. 19, No. 4, 21.08.2000, p. 296-300.

Research output: Contribution to journalArticle

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