Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction

Joon Sup Yeom, Se-Ho Park, Seung Ho Ryu, Hae Kyung Park, So Youn Woo, Eun Hee Ha, Bo Eun Lee, Kwon Yoo, Joo Ho Lee, Kwang Ho Kim, Sunhil Kim, Young A. Kim, Sun Young Ahn, Sejoong Oh, Hyung Joo Park, Gi Sik Min, Ju Young Seoh, Jae Won Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (± SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 ± 0.24 and 22.5 ± 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-β. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-α, and interferon-γ than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations.

Original languageEnglish
Pages (from-to)687-691
Number of pages5
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume97
Issue number6
DOIs
Publication statusPublished - 2003 Nov 1

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Vivax Malaria
Cytokines
Liver
Serum
Military Hospitals
Republic of Korea
Fas Ligand Protein
Interleukins
Transforming Growth Factors
Interleukin-12
Body Temperature
Platelet Count
Leukocyte Count
Hematocrit
Interleukin-4
Interleukin-10
Interferons
Population
Interleukin-6
Parasites

Keywords

  • Cytokines
  • Hepatic dysfunction
  • Malaria
  • Plasmodium vivax
  • South Korea

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

Cite this

Serum cytokine profiles in patients with Plasmodium vivax malaria : A comparison between those who presented with and without hepatic dysfunction. / Yeom, Joon Sup; Park, Se-Ho; Ryu, Seung Ho; Park, Hae Kyung; Woo, So Youn; Ha, Eun Hee; Lee, Bo Eun; Yoo, Kwon; Lee, Joo Ho; Kim, Kwang Ho; Kim, Sunhil; Kim, Young A.; Ahn, Sun Young; Oh, Sejoong; Park, Hyung Joo; Min, Gi Sik; Seoh, Ju Young; Park, Jae Won.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 97, No. 6, 01.11.2003, p. 687-691.

Research output: Contribution to journalArticle

Yeom, JS, Park, S-H, Ryu, SH, Park, HK, Woo, SY, Ha, EH, Lee, BE, Yoo, K, Lee, JH, Kim, KH, Kim, S, Kim, YA, Ahn, SY, Oh, S, Park, HJ, Min, GS, Seoh, JY & Park, JW 2003, 'Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 97, no. 6, pp. 687-691. https://doi.org/10.1016/S0035-9203(03)80104-9
Yeom, Joon Sup ; Park, Se-Ho ; Ryu, Seung Ho ; Park, Hae Kyung ; Woo, So Youn ; Ha, Eun Hee ; Lee, Bo Eun ; Yoo, Kwon ; Lee, Joo Ho ; Kim, Kwang Ho ; Kim, Sunhil ; Kim, Young A. ; Ahn, Sun Young ; Oh, Sejoong ; Park, Hyung Joo ; Min, Gi Sik ; Seoh, Ju Young ; Park, Jae Won. / Serum cytokine profiles in patients with Plasmodium vivax malaria : A comparison between those who presented with and without hepatic dysfunction. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2003 ; Vol. 97, No. 6. pp. 687-691.
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abstract = "The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (± SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 ± 0.24 and 22.5 ± 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-β. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-α, and interferon-γ than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations.",
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AU - Park, Hae Kyung

AU - Woo, So Youn

AU - Ha, Eun Hee

AU - Lee, Bo Eun

AU - Yoo, Kwon

AU - Lee, Joo Ho

AU - Kim, Kwang Ho

AU - Kim, Sunhil

AU - Kim, Young A.

AU - Ahn, Sun Young

AU - Oh, Sejoong

AU - Park, Hyung Joo

AU - Min, Gi Sik

AU - Seoh, Ju Young

AU - Park, Jae Won

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