Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hyperpyrexia

Ju Young Seoh, Mohammad Khan, Se-Ho Park, Hae Kyung Park, Myong Heon Shin, Eun Hee Ha, Bo Eun Lee, Kwon Yoo, Ho Seong Han, Sejoong Oh, Jun Hwan Wi, Chang Kwon Hong, Chang Hyun Oh, Young A. Kim, Jae Won Park

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26 Citations (Scopus)

Abstract

Serum cytokine profiles in patients with Plasmodium vivax malaria who presented with and without hyperpyrexia were compared by a retrospective review of the medical records of the consecutive patients seen at the military hospitals near the demilitarized zone in the Republic of Korea from April 2000 through October 2001. Of 162 male patients studied, 120 (86.4%) presented with hyperpyrexia (i.e., an axillary temperature ≥ 40°C). The mean ± SEM ages of the patients with and without hyperpyrexia were 21.5 ± 0.14 and 21.9 ± 0.39 years, respectively (P = 0.33). The mean ± SEM concentrations of serum interleukin (IL)-6 (379.7 ± 44.1 pg/mL versus 105.4 ± 26.8 pg/mL; P = 0.002), IL-10 (583.4 ± 58.2 pg/mL versus 142.4 ± 39.7 pg/mL; P = 0.0001), and interferon-γ (312.6 ± 33.9 pg/mL versus 11.2.9 ± 27.1 pg/mL; P = 0.0001) were significantly higher in patients with hyperpyrexia compared with those without hyperpyrexia. The mean ± SEM concentrations of serum tumor necrosis factor-α were 155.5 ± 54.5 pg/mL and 109.9 ± 29.3 pg/mL (P = 0.27) in patients who presented with and without hyperpyrexia, respectively. Further studies are needed to examine whether serum concentrations of these cytokines also parallel their concentrations at the tissue sites of their production and action.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume68
Issue number1
Publication statusPublished - 2003 Jan 1

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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    Seoh, J. Y., Khan, M., Park, S-H., Park, H. K., Shin, M. H., Ha, E. H., Lee, B. E., Yoo, K., Han, H. S., Oh, S., Wi, J. H., Hong, C. K., Oh, C. H., Kim, Y. A., & Park, J. W. (2003). Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hyperpyrexia. American Journal of Tropical Medicine and Hygiene, 68(1), 102-106.