Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women

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15 Citations (Scopus)

Abstract

Objective: Ferritin, a marker of total body iron stores, is known to be associated with the risk of having metabolic syndrome and has been demonstrated to increase after the onset of menopause. Postmenopause status is an important determinant of metabolic syndrome. The aim of this study was to perform a menopause status-specific analysis of the association between ferritin levels and metabolic syndrome. Methods: We conducted a cross-sectional study of 3,082 participants (1,691 premenopausal women and 1,391 postmenopausal women), all of whom were enrolled in the Korean National Health and Nutrition Examination Survey 2007. Results: Premenopausal and postmenopausal women with metabolic syndrome had higher ferritin levels than did those without metabolic syndrome. After adjustments for age; body mass index; alcohol intake; smoking history; exercise; hormone therapy use; hemoglobin, aspartate aminotransferase, and alanine aminotransferase levels; and intake of energy and iron, multivariate logistic regression analysis revealed that postmenopausal women with ferritin levels in the third tertile had an increased risk of having metabolic syndrome (odds ratio, 1.62; 95% CI, 1.04-2.81) compared with postmenopausal women with levels in the first quartile. No such association was detected in premenopausal women. Conclusions: Increased ferritin levels may be a determinant for metabolic syndrome in postmenopausal women but not in premenopausal women.

Original languageEnglish
Pages (from-to)1120-1124
Number of pages5
JournalMenopause
Volume18
Issue number10
DOIs
Publication statusPublished - 2011 Oct 1

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Ferritins
Serum
Menopause
Iron
Postmenopause
Nutrition Surveys
Aspartate Aminotransferases
Energy Intake
Alanine Transaminase
Hemoglobins
Body Mass Index
Cross-Sectional Studies
Logistic Models
Smoking
History
Odds Ratio
Regression Analysis
Alcohols
Hormones
Exercise

Keywords

  • Ferritin
  • Menopause
  • Metabolic syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women",
abstract = "Objective: Ferritin, a marker of total body iron stores, is known to be associated with the risk of having metabolic syndrome and has been demonstrated to increase after the onset of menopause. Postmenopause status is an important determinant of metabolic syndrome. The aim of this study was to perform a menopause status-specific analysis of the association between ferritin levels and metabolic syndrome. Methods: We conducted a cross-sectional study of 3,082 participants (1,691 premenopausal women and 1,391 postmenopausal women), all of whom were enrolled in the Korean National Health and Nutrition Examination Survey 2007. Results: Premenopausal and postmenopausal women with metabolic syndrome had higher ferritin levels than did those without metabolic syndrome. After adjustments for age; body mass index; alcohol intake; smoking history; exercise; hormone therapy use; hemoglobin, aspartate aminotransferase, and alanine aminotransferase levels; and intake of energy and iron, multivariate logistic regression analysis revealed that postmenopausal women with ferritin levels in the third tertile had an increased risk of having metabolic syndrome (odds ratio, 1.62; 95{\%} CI, 1.04-2.81) compared with postmenopausal women with levels in the first quartile. No such association was detected in premenopausal women. Conclusions: Increased ferritin levels may be a determinant for metabolic syndrome in postmenopausal women but not in premenopausal women.",
keywords = "Ferritin, Menopause, Metabolic syndrome",
author = "Geum-Joon Cho and Jung-Ho Shin and Yi, {Kyong Wook} and Hyun-Tae Park and Tak Kim and Hur, {Jun Young} and Kim, {Sun Haeng}",
year = "2011",
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T1 - Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women

AU - Cho, Geum-Joon

AU - Shin, Jung-Ho

AU - Yi, Kyong Wook

AU - Park, Hyun-Tae

AU - Kim, Tak

AU - Hur, Jun Young

AU - Kim, Sun Haeng

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Objective: Ferritin, a marker of total body iron stores, is known to be associated with the risk of having metabolic syndrome and has been demonstrated to increase after the onset of menopause. Postmenopause status is an important determinant of metabolic syndrome. The aim of this study was to perform a menopause status-specific analysis of the association between ferritin levels and metabolic syndrome. Methods: We conducted a cross-sectional study of 3,082 participants (1,691 premenopausal women and 1,391 postmenopausal women), all of whom were enrolled in the Korean National Health and Nutrition Examination Survey 2007. Results: Premenopausal and postmenopausal women with metabolic syndrome had higher ferritin levels than did those without metabolic syndrome. After adjustments for age; body mass index; alcohol intake; smoking history; exercise; hormone therapy use; hemoglobin, aspartate aminotransferase, and alanine aminotransferase levels; and intake of energy and iron, multivariate logistic regression analysis revealed that postmenopausal women with ferritin levels in the third tertile had an increased risk of having metabolic syndrome (odds ratio, 1.62; 95% CI, 1.04-2.81) compared with postmenopausal women with levels in the first quartile. No such association was detected in premenopausal women. Conclusions: Increased ferritin levels may be a determinant for metabolic syndrome in postmenopausal women but not in premenopausal women.

AB - Objective: Ferritin, a marker of total body iron stores, is known to be associated with the risk of having metabolic syndrome and has been demonstrated to increase after the onset of menopause. Postmenopause status is an important determinant of metabolic syndrome. The aim of this study was to perform a menopause status-specific analysis of the association between ferritin levels and metabolic syndrome. Methods: We conducted a cross-sectional study of 3,082 participants (1,691 premenopausal women and 1,391 postmenopausal women), all of whom were enrolled in the Korean National Health and Nutrition Examination Survey 2007. Results: Premenopausal and postmenopausal women with metabolic syndrome had higher ferritin levels than did those without metabolic syndrome. After adjustments for age; body mass index; alcohol intake; smoking history; exercise; hormone therapy use; hemoglobin, aspartate aminotransferase, and alanine aminotransferase levels; and intake of energy and iron, multivariate logistic regression analysis revealed that postmenopausal women with ferritin levels in the third tertile had an increased risk of having metabolic syndrome (odds ratio, 1.62; 95% CI, 1.04-2.81) compared with postmenopausal women with levels in the first quartile. No such association was detected in premenopausal women. Conclusions: Increased ferritin levels may be a determinant for metabolic syndrome in postmenopausal women but not in premenopausal women.

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