Serum ferritin levels are positively associated with bone mineral density in elderly Korean men: the 2008–2010 Korea National Health and Nutrition Examination Surveys

Kyung Shik Lee, Ji Su Jang, Dong Ryul Lee, Yang-Hyun Kim, Ga Eun Nam, Byoung duck Han, Kyung Do Han, Kyung-Hwan Cho, Seon Mee Kim, Youn Seon Choi, Do-Hoon Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A possible negative effect of iron overload on bone metabolism has been suggested by the fact that patients with hemochromatosis, thalassemia, and sickle cell anemia have lower bone mineral density than the general population. However, the influence of iron overload on bone health in the general population is uncertain. The aim of this study was to investigate the relationship between serum ferritin levels and bone mineral density (BMD) in elderly Koreans. A total of 2,943 subjects aged 65 years and over who participated in the 2008–2010 Korea National Health and Nutrition Examination Surveys were included in this study. Age, physical activity, current smoking status, alcohol consumption, education level, household income, and dietary assessment were surveyed by a face-to-face interview. BMD was measured at the lumbar spine and femur by dual-energy X-ray absorptiometry, and other biochemical markers, including serum ferritin, 25-hydroxyvitamin D3, serum alkaline phosphatase, and parathyroid hormone, were assayed. After adjusting for age and body mass index, we found an association between BMD of the total lumbar spine, total femur, and femur neck and levels of alkaline phosphatase, parathyroid hormone, vitamin D3, and daily intake of calcium and protein. Serum ferritin levels were positively associated with BMD of the total lumbar spine, total femur, and femur neck after adjusting for all covariates in men, but not in women. This study suggests a positive association between serum ferritin levels and BMD in elderly South Korean men without hematologic disorders. Further study is warranted to verify the effects of iron on bone metabolism.

Original languageEnglish
Pages (from-to)683-690
Number of pages8
JournalJournal of Bone and Mineral Metabolism
Volume32
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Nutrition Surveys
Ferritins
Korea
Bone Density
Serum
Femur
Spine
Iron Overload
Femur Neck
Parathyroid Hormone
Bone and Bones
Alkaline Phosphatase
Calcifediol
Thalassemia
Hemochromatosis
Cholecalciferol
Photon Absorptiometry
Sickle Cell Anemia
Alcohol Drinking
Population

Keywords

  • Bone mineral density
  • Elderly
  • Ferritin
  • Iron
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Serum ferritin levels are positively associated with bone mineral density in elderly Korean men : the 2008–2010 Korea National Health and Nutrition Examination Surveys. / Lee, Kyung Shik; Jang, Ji Su; Lee, Dong Ryul; Kim, Yang-Hyun; Nam, Ga Eun; Han, Byoung duck; Do Han, Kyung; Cho, Kyung-Hwan; Kim, Seon Mee; Choi, Youn Seon; Kim, Do-Hoon.

In: Journal of Bone and Mineral Metabolism, Vol. 32, No. 6, 01.01.2014, p. 683-690.

Research output: Contribution to journalArticle

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abstract = "A possible negative effect of iron overload on bone metabolism has been suggested by the fact that patients with hemochromatosis, thalassemia, and sickle cell anemia have lower bone mineral density than the general population. However, the influence of iron overload on bone health in the general population is uncertain. The aim of this study was to investigate the relationship between serum ferritin levels and bone mineral density (BMD) in elderly Koreans. A total of 2,943 subjects aged 65 years and over who participated in the 2008–2010 Korea National Health and Nutrition Examination Surveys were included in this study. Age, physical activity, current smoking status, alcohol consumption, education level, household income, and dietary assessment were surveyed by a face-to-face interview. BMD was measured at the lumbar spine and femur by dual-energy X-ray absorptiometry, and other biochemical markers, including serum ferritin, 25-hydroxyvitamin D3, serum alkaline phosphatase, and parathyroid hormone, were assayed. After adjusting for age and body mass index, we found an association between BMD of the total lumbar spine, total femur, and femur neck and levels of alkaline phosphatase, parathyroid hormone, vitamin D3, and daily intake of calcium and protein. Serum ferritin levels were positively associated with BMD of the total lumbar spine, total femur, and femur neck after adjusting for all covariates in men, but not in women. This study suggests a positive association between serum ferritin levels and BMD in elderly South Korean men without hematologic disorders. Further study is warranted to verify the effects of iron on bone metabolism.",
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