Serum ferritin levels are positively associated with metabolically obese normal weight: A nationwide population-based study

Jae Woo Kim, Do-Hoon Kim, Yong Kyun Roh, Sang Yhun Ju, Hyo Yun Nam, Ga Eun Nam, Dong Won Kim, Seung Hyun Lee, Chung Woo Lee, Kyungdo Han, Yong Gyu Park

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Abstract

The purpose of this study was to examine the relationship between serum ferritin levels and metabolically obese normal weight (MONW) and to determine the appropriate cut-off value of serum ferritin for the prediction of clinical metabolic status in nonobese Korean adults. Data from 9411 participants in the fourth (2008) and fifth (2010) annual Korea National Health and Nutrition Examination Surveys were used in this study. MONW was determined by combining National Cholesterol Education Program Adult Treatment Panel III criteria, Wildman criteria, and homeostatic model assessment criteria for metabolic healthy obesity. The mean serum ferritin level was 103.5 1.2 ng/mL in men and 45.5 0.6 ng/mL in women. The estimated cutoff value of serum ferritin for the prediction of MONW was 127.03 ng/mL in men and 46.87 ng/mL in women. Both men and women who had higher serum ferritin levels than the cutoff value had a higher prevalence of MONW than those individuals who had lower serum ferritin levels than the cutoff value. In the final multivariable adjusted logistic regression model, the odds ratio (95% confidence interval) of MONW in the subjects who had higher serum ferritin levels than the cutoff value was 1.631 (1.312-2.028) in men and 1.298 (1-1.685) in women. In this study, serum ferritin levels were positively associated with MONW, and those subjects who had higher serum ferritin levels than the cutoff value had a higher prevalence and a higher adjusted odds ratio for MONW despite being nonobese.

Original languageEnglish
Article numbere2335
JournalMedicine (United States)
Volume94
Issue number52
DOIs
Publication statusPublished - 2015 Jan 1

ASJC Scopus subject areas

  • Medicine(all)

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    Kim, J. W., Kim, D-H., Roh, Y. K., Ju, S. Y., Nam, H. Y., Nam, G. E., Kim, D. W., Lee, S. H., Lee, C. W., Han, K., & Park, Y. G. (2015). Serum ferritin levels are positively associated with metabolically obese normal weight: A nationwide population-based study. Medicine (United States), 94(52), [e2335]. https://doi.org/10.1097/MD.0000000000002335