Serum gamma-glutamyltransferase levels are associated with concomitant cardiovascular risk factors in Korean hypertensive patients: A nationwide population-based study

Sangsu Lee, Do-Hoon Kim, Hyo Yun Nam, Yong Kyun Roh, Sang Yhun Ju, Yeo Joon Yoon, Ga Eun Nam, Jun Seok Choi, Jong Eun Lee, Jung Eun Sang, Kyungdo Han, Yong Gyu Park

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Abstract

Previous studies suggested that serum gamma-glutamyltransferase (GGT) levels were associated with the prevalence of cardiovascular disease (CVD) risk factors including hypertension, diabetes mellitus (DM), and metabolic syndrome (MetS) in the general population. We aimed to investigate the relationship between serum GGT levels and CVD risk factors in Korean hypertensive patients. This cross-sectional study was based on data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2011 to 2012. The analysis included 1541 hypertensive participants. Study participants were divided into groups according to tertiles of serum GGT with cutoff points of 20 and 35 U/L. Serum GGT levels were positively associated with the components of MetS (P value<0.05, except for systolic blood pressure and highdensity lipoprotein cholesterol). After adjusting for possible confounders, serumGGT levelswere associated with an increased risk of MetS, high waist circumference, high triglyceride level, fasting plasma glucose, DM, and the urinary albumin-to-creatinine ratio (P=0.001). In hypertensive patients, serum GGT levels are positively associated with major cardiovascular risk factors such as MetS, DM, and urinary albumin excretion.

Original languageEnglish
Article number2171
JournalMedicine (United States)
Volume94
Issue number50
DOIs
Publication statusPublished - 2015 Jan 1

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gamma-Glutamyltransferase
Serum
Diabetes Mellitus
Population
Albumins
Cardiovascular Diseases
Blood Pressure
Nutrition Surveys
Waist Circumference
Korea
Fasting
Creatinine
Triglycerides
Cross-Sectional Studies
Hypertension
Glucose

ASJC Scopus subject areas

  • Medicine(all)

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Serum gamma-glutamyltransferase levels are associated with concomitant cardiovascular risk factors in Korean hypertensive patients : A nationwide population-based study. / Lee, Sangsu; Kim, Do-Hoon; Nam, Hyo Yun; Roh, Yong Kyun; Ju, Sang Yhun; Yoon, Yeo Joon; Nam, Ga Eun; Choi, Jun Seok; Lee, Jong Eun; Sang, Jung Eun; Han, Kyungdo; Park, Yong Gyu.

In: Medicine (United States), Vol. 94, No. 50, 2171, 01.01.2015.

Research output: Contribution to journalArticle

Lee, Sangsu ; Kim, Do-Hoon ; Nam, Hyo Yun ; Roh, Yong Kyun ; Ju, Sang Yhun ; Yoon, Yeo Joon ; Nam, Ga Eun ; Choi, Jun Seok ; Lee, Jong Eun ; Sang, Jung Eun ; Han, Kyungdo ; Park, Yong Gyu. / Serum gamma-glutamyltransferase levels are associated with concomitant cardiovascular risk factors in Korean hypertensive patients : A nationwide population-based study. In: Medicine (United States). 2015 ; Vol. 94, No. 50.
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