Serum kisspeptin levels in Korean girls with central precocious puberty

Young Jun Rhie, Kee Hyoung Lee, So Hee Eun, Byung Min Choi, Hyun Wook Chae, Ah Reum Kwon, Woo Jung Lee, Jung Hyun Kim, Ho Seong Kim

    Research output: Contribution to journalArticlepeer-review

    29 Citations (Scopus)

    Abstract

    Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.

    Original languageEnglish
    Pages (from-to)927-931
    Number of pages5
    JournalJournal of Korean medical science
    Volume26
    Issue number7
    DOIs
    Publication statusPublished - 2011 Jul

    Keywords

    • Central precocious puberty
    • G-protein coupled receptor-54
    • Gonadotropin-releasing hormone
    • KISS1 gene
    • Kisspeptin

    ASJC Scopus subject areas

    • Medicine(all)

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