Serum kisspeptin levels in Korean girls with central precocious puberty

Young-Jun Rhie, Kee Hyoung Lee, So-Hee Eun, Byung Min Choi, Hyun Wook Chae, Ah Reum Kwon, Woo Jung Lee, Jung Hyun Kim, Ho Seong Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.

Original languageEnglish
Pages (from-to)927-931
Number of pages5
JournalJournal of Korean Medical Science
Volume26
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Kisspeptins
Serum
Luteinizing Hormone
Gonadotropin-Releasing Hormone
Central Precocious Puberty
Pituitary Hormone-Releasing Hormones
Puberty
G-Protein-Coupled Receptors
Immunoenzyme Techniques

Keywords

  • Central precocious puberty
  • G-protein coupled receptor-54
  • Gonadotropin-releasing hormone
  • KISS1 gene
  • Kisspeptin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Serum kisspeptin levels in Korean girls with central precocious puberty. / Rhie, Young-Jun; Lee, Kee Hyoung; Eun, So-Hee; Choi, Byung Min; Chae, Hyun Wook; Kwon, Ah Reum; Lee, Woo Jung; Kim, Jung Hyun; Kim, Ho Seong.

In: Journal of Korean Medical Science, Vol. 26, No. 7, 01.07.2011, p. 927-931.

Research output: Contribution to journalArticle

Rhie, Young-Jun ; Lee, Kee Hyoung ; Eun, So-Hee ; Choi, Byung Min ; Chae, Hyun Wook ; Kwon, Ah Reum ; Lee, Woo Jung ; Kim, Jung Hyun ; Kim, Ho Seong. / Serum kisspeptin levels in Korean girls with central precocious puberty. In: Journal of Korean Medical Science. 2011 ; Vol. 26, No. 7. pp. 927-931.
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