Serum long-chain n-3 polyunsaturated fatty acids and aortic calcification in middle-aged men: The population-based cross-sectional ERA-JUMP study

Hemant Mahajan, Jina Choo, Kamal Masaki, Akira Fujiyoshi, Jingchuan Guo, Rhobert Evans, Siyi Shangguan, Bradley Willcox, Emma Barinas-Mitchell, Aya Kadota, Katsuyuki Miura, Lewis Kuller, Chol Shin, Hirotusugu Ueshima, Akira Sekikawa

Research output: Contribution to journalArticle

Abstract

Background and aim: Few studies have examined the association of long-chain n-3 polyunsaturated fatty acids (LCn-3PUFAs)with the measures of atherosclerosis in the general population. This study aimed to examine the relationship of total LCn-3PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)with aortic calcification. Methods and results: In a multiethnic population-based cross-sectional study of 998 asymptomatic men aged 40–49 years (300 US-White, 101 US-Black, 287 Japanese American, and 310 Japanese in Japan), we examined the relationship of serum LCn-3PUFAs to aortic calcification (measured by electron-beam computed tomography and quantified using the Agatston method)using Tobit regression and ordinal logistic regression after adjusting for potential confounders. Overall 56.5% participants had an aortic calcification score (AoCaS)> 0. The means (SD)of total LCn-3PUFAs, EPA, and DHA were 5.8% (3.3%), 1.4% (1.3%), and 3.7% (2.1%), respectively. In multivariable-adjusted Tobit regression, a 1-SD increase in total LCn-3PUFAs, EPA, and DHA was associated with 29% (95% CI = 0.51, 1.00), 9% (95% CI = 0.68, 1.23), and 35% (95% CI = 0.46, 0.91)lower AoCaS, respectively. Results were similar in ordinal logistic regression analysis. There was no significant interaction between race/ethnicity and total LCn–3PUFAs, EPA or DHA on aortic calcification. Conclusions: This study showed the significant inverse association of LCn-3PUFAs with aortic calcification independent of conventional cardiovascular risk factors among men in the general population. This association appeared to be driven by DHA but not EPA.

Original languageEnglish
JournalNutrition, Metabolism and Cardiovascular Diseases
DOIs
Publication statusPublished - 2019 Jan 1

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Omega-3 Fatty Acids
Eicosapentaenoic Acid
Docosahexaenoic Acids
Serum
Population
Logistic Models
X Ray Computed Tomography
Asian Americans
Atherosclerosis
Japan
Cross-Sectional Studies
Regression Analysis

Keywords

  • Aorta
  • Atherosclerosis
  • DHA
  • EPA
  • PUFA

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Serum long-chain n-3 polyunsaturated fatty acids and aortic calcification in middle-aged men : The population-based cross-sectional ERA-JUMP study. / Mahajan, Hemant; Choo, Jina; Masaki, Kamal; Fujiyoshi, Akira; Guo, Jingchuan; Evans, Rhobert; Shangguan, Siyi; Willcox, Bradley; Barinas-Mitchell, Emma; Kadota, Aya; Miura, Katsuyuki; Kuller, Lewis; Shin, Chol; Ueshima, Hirotusugu; Sekikawa, Akira.

In: Nutrition, Metabolism and Cardiovascular Diseases, 01.01.2019.

Research output: Contribution to journalArticle

Mahajan, H, Choo, J, Masaki, K, Fujiyoshi, A, Guo, J, Evans, R, Shangguan, S, Willcox, B, Barinas-Mitchell, E, Kadota, A, Miura, K, Kuller, L, Shin, C, Ueshima, H & Sekikawa, A 2019, 'Serum long-chain n-3 polyunsaturated fatty acids and aortic calcification in middle-aged men: The population-based cross-sectional ERA-JUMP study', Nutrition, Metabolism and Cardiovascular Diseases. https://doi.org/10.1016/j.numecd.2019.04.011
Mahajan, Hemant ; Choo, Jina ; Masaki, Kamal ; Fujiyoshi, Akira ; Guo, Jingchuan ; Evans, Rhobert ; Shangguan, Siyi ; Willcox, Bradley ; Barinas-Mitchell, Emma ; Kadota, Aya ; Miura, Katsuyuki ; Kuller, Lewis ; Shin, Chol ; Ueshima, Hirotusugu ; Sekikawa, Akira. / Serum long-chain n-3 polyunsaturated fatty acids and aortic calcification in middle-aged men : The population-based cross-sectional ERA-JUMP study. In: Nutrition, Metabolism and Cardiovascular Diseases. 2019.
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abstract = "Background and aim: Few studies have examined the association of long-chain n-3 polyunsaturated fatty acids (LCn-3PUFAs)with the measures of atherosclerosis in the general population. This study aimed to examine the relationship of total LCn-3PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)with aortic calcification. Methods and results: In a multiethnic population-based cross-sectional study of 998 asymptomatic men aged 40–49 years (300 US-White, 101 US-Black, 287 Japanese American, and 310 Japanese in Japan), we examined the relationship of serum LCn-3PUFAs to aortic calcification (measured by electron-beam computed tomography and quantified using the Agatston method)using Tobit regression and ordinal logistic regression after adjusting for potential confounders. Overall 56.5{\%} participants had an aortic calcification score (AoCaS)> 0. The means (SD)of total LCn-3PUFAs, EPA, and DHA were 5.8{\%} (3.3{\%}), 1.4{\%} (1.3{\%}), and 3.7{\%} (2.1{\%}), respectively. In multivariable-adjusted Tobit regression, a 1-SD increase in total LCn-3PUFAs, EPA, and DHA was associated with 29{\%} (95{\%} CI = 0.51, 1.00), 9{\%} (95{\%} CI = 0.68, 1.23), and 35{\%} (95{\%} CI = 0.46, 0.91)lower AoCaS, respectively. Results were similar in ordinal logistic regression analysis. There was no significant interaction between race/ethnicity and total LCn–3PUFAs, EPA or DHA on aortic calcification. Conclusions: This study showed the significant inverse association of LCn-3PUFAs with aortic calcification independent of conventional cardiovascular risk factors among men in the general population. This association appeared to be driven by DHA but not EPA.",
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AU - Masaki, Kamal

AU - Fujiyoshi, Akira

AU - Guo, Jingchuan

AU - Evans, Rhobert

AU - Shangguan, Siyi

AU - Willcox, Bradley

AU - Barinas-Mitchell, Emma

AU - Kadota, Aya

AU - Miura, Katsuyuki

AU - Kuller, Lewis

AU - Shin, Chol

AU - Ueshima, Hirotusugu

AU - Sekikawa, Akira

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