Serum osteocalcin levels in overweight children

Seok Bin Oh, Won Young Lee, Hyo-Kyoung Nam, Young-Jun Rhie, Kee Hyoung Lee

Research output: Contribution to journalArticle

Abstract

Purpose: Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass, and mitochondrial proliferation and functional enhancement. This study aimed to determine serum osteocalcin levels in overweight children and to investigate the relationships of osteocalcin with glucose metabolism and insulin sensitivity. Methods: After overnight fasting, serum osteocalcin levels were measured in overweight (n=50) children between 6.0 and 12.9 years of age and nonoverweight controls (n=60). Height, weight, fasting serum glucose, insulin, alkaline phosphatase, total cholesterol, and 25 hydroxy vitamin D3 (25(OH)VitD3) were also measured in all subjects. Results: There were significant differences in serum osteocalcin levels between the overweight and control groups (64.00±20.44 vs. 89.56±28.63, P<0.001). Serum osteocalcin levels were inversely correlated with body mass index (BMI) (r=-0.283, P=0.003), weight standard deviation score (SDS) (r=-0.222, P=0.020), BMI SDS (r=-0.297, P=0.002), insulin (r=-0.313, P=0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) index (r=-0.268, P=0.005). In the subsequent multiple regression analyses, BMI, HOMA-IR, and age were determined to be independent predicting factors for serum osteocalcin. Conclusion: Our findings showed associations of serum osteocalcin with glucose metabolism and insulin sensitivity in overweight children, but we could not establish a causal relationship.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalAnnals of Pediatric Endocrinology and Metabolism
Volume24
Issue number2
DOIs
Publication statusPublished - 2019 Jun 1

Fingerprint

Osteocalcin
Serum
Insulin Resistance
Glucose
Body Mass Index
Fasting
Homeostasis
Insulin
Weights and Measures
Cholecalciferol
Energy Metabolism
Alkaline Phosphatase
Fats
Cholesterol
Regression Analysis
Bone and Bones
Control Groups

Keywords

  • Glucose
  • Metabolism
  • Osteocalcin
  • Overweight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum osteocalcin levels in overweight children. / Oh, Seok Bin; Lee, Won Young; Nam, Hyo-Kyoung; Rhie, Young-Jun; Lee, Kee Hyoung.

In: Annals of Pediatric Endocrinology and Metabolism, Vol. 24, No. 2, 01.06.2019, p. 104-107.

Research output: Contribution to journalArticle

@article{a3cf30e2481e47f880d7098e74e0d9f7,
title = "Serum osteocalcin levels in overweight children",
abstract = "Purpose: Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass, and mitochondrial proliferation and functional enhancement. This study aimed to determine serum osteocalcin levels in overweight children and to investigate the relationships of osteocalcin with glucose metabolism and insulin sensitivity. Methods: After overnight fasting, serum osteocalcin levels were measured in overweight (n=50) children between 6.0 and 12.9 years of age and nonoverweight controls (n=60). Height, weight, fasting serum glucose, insulin, alkaline phosphatase, total cholesterol, and 25 hydroxy vitamin D3 (25(OH)VitD3) were also measured in all subjects. Results: There were significant differences in serum osteocalcin levels between the overweight and control groups (64.00±20.44 vs. 89.56±28.63, P<0.001). Serum osteocalcin levels were inversely correlated with body mass index (BMI) (r=-0.283, P=0.003), weight standard deviation score (SDS) (r=-0.222, P=0.020), BMI SDS (r=-0.297, P=0.002), insulin (r=-0.313, P=0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) index (r=-0.268, P=0.005). In the subsequent multiple regression analyses, BMI, HOMA-IR, and age were determined to be independent predicting factors for serum osteocalcin. Conclusion: Our findings showed associations of serum osteocalcin with glucose metabolism and insulin sensitivity in overweight children, but we could not establish a causal relationship.",
keywords = "Glucose, Metabolism, Osteocalcin, Overweight",
author = "Oh, {Seok Bin} and Lee, {Won Young} and Hyo-Kyoung Nam and Young-Jun Rhie and Lee, {Kee Hyoung}",
year = "2019",
month = "6",
day = "1",
doi = "10.6065/apem.2019.24.2.104",
language = "English",
volume = "24",
pages = "104--107",
journal = "Annals of Pediatric Endocrinology and Metabolism",
issn = "2287-1012",
publisher = "Korean society of pediatric endocrinology",
number = "2",

}

TY - JOUR

T1 - Serum osteocalcin levels in overweight children

AU - Oh, Seok Bin

AU - Lee, Won Young

AU - Nam, Hyo-Kyoung

AU - Rhie, Young-Jun

AU - Lee, Kee Hyoung

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Purpose: Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass, and mitochondrial proliferation and functional enhancement. This study aimed to determine serum osteocalcin levels in overweight children and to investigate the relationships of osteocalcin with glucose metabolism and insulin sensitivity. Methods: After overnight fasting, serum osteocalcin levels were measured in overweight (n=50) children between 6.0 and 12.9 years of age and nonoverweight controls (n=60). Height, weight, fasting serum glucose, insulin, alkaline phosphatase, total cholesterol, and 25 hydroxy vitamin D3 (25(OH)VitD3) were also measured in all subjects. Results: There were significant differences in serum osteocalcin levels between the overweight and control groups (64.00±20.44 vs. 89.56±28.63, P<0.001). Serum osteocalcin levels were inversely correlated with body mass index (BMI) (r=-0.283, P=0.003), weight standard deviation score (SDS) (r=-0.222, P=0.020), BMI SDS (r=-0.297, P=0.002), insulin (r=-0.313, P=0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) index (r=-0.268, P=0.005). In the subsequent multiple regression analyses, BMI, HOMA-IR, and age were determined to be independent predicting factors for serum osteocalcin. Conclusion: Our findings showed associations of serum osteocalcin with glucose metabolism and insulin sensitivity in overweight children, but we could not establish a causal relationship.

AB - Purpose: Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure, reduction of fat mass, and mitochondrial proliferation and functional enhancement. This study aimed to determine serum osteocalcin levels in overweight children and to investigate the relationships of osteocalcin with glucose metabolism and insulin sensitivity. Methods: After overnight fasting, serum osteocalcin levels were measured in overweight (n=50) children between 6.0 and 12.9 years of age and nonoverweight controls (n=60). Height, weight, fasting serum glucose, insulin, alkaline phosphatase, total cholesterol, and 25 hydroxy vitamin D3 (25(OH)VitD3) were also measured in all subjects. Results: There were significant differences in serum osteocalcin levels between the overweight and control groups (64.00±20.44 vs. 89.56±28.63, P<0.001). Serum osteocalcin levels were inversely correlated with body mass index (BMI) (r=-0.283, P=0.003), weight standard deviation score (SDS) (r=-0.222, P=0.020), BMI SDS (r=-0.297, P=0.002), insulin (r=-0.313, P=0.001), and homeostasis model assessment of insulin resistance (HOMA-IR) index (r=-0.268, P=0.005). In the subsequent multiple regression analyses, BMI, HOMA-IR, and age were determined to be independent predicting factors for serum osteocalcin. Conclusion: Our findings showed associations of serum osteocalcin with glucose metabolism and insulin sensitivity in overweight children, but we could not establish a causal relationship.

KW - Glucose

KW - Metabolism

KW - Osteocalcin

KW - Overweight

UR - http://www.scopus.com/inward/record.url?scp=85070680067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070680067&partnerID=8YFLogxK

U2 - 10.6065/apem.2019.24.2.104

DO - 10.6065/apem.2019.24.2.104

M3 - Article

AN - SCOPUS:85070680067

VL - 24

SP - 104

EP - 107

JO - Annals of Pediatric Endocrinology and Metabolism

JF - Annals of Pediatric Endocrinology and Metabolism

SN - 2287-1012

IS - 2

ER -