Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity

Seon Mee Kim, J. Leet, O. H. Ryu, K. W. Lee, H. Y. Kim, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, D. S. Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

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Abstract

Objective: We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients. Patients and measurements: The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured. Results: Serum OPG levels (6.1 ± 1.4 vs. 5.4 ± 1.3 pmol/l, P = 0.011) and baPWV (1562 ± 354 vs. 1399 ± 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R2 = 0.299). Conclusions: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

Original languageEnglish
Pages (from-to)594-598
Number of pages5
JournalClinical Endocrinology
Volume63
Issue number5
DOIs
Publication statusPublished - 2005 Nov 1

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Osteoprotegerin
Pulse Wave Analysis
Ankle
Inflammation
Arm
Serum
Blood Pressure
C-Reactive Protein
Blood Glucose
Interleukin-6
Fasting
Vascular Stiffness
Glucose
Insulin Resistance
Triglycerides
Homeostasis
Regression Analysis
Lipids

ASJC Scopus subject areas

  • Endocrinology

Cite this

Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity. / Kim, Seon Mee; Leet, J.; Ryu, O. H.; Lee, K. W.; Kim, H. Y.; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei-Hyun; Choi, D. S.; Choi, Kyung Mook.

In: Clinical Endocrinology, Vol. 63, No. 5, 01.11.2005, p. 594-598.

Research output: Contribution to journalArticle

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abstract = "Objective: We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients. Patients and measurements: The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured. Results: Serum OPG levels (6.1 ± 1.4 vs. 5.4 ± 1.3 pmol/l, P = 0.011) and baPWV (1562 ± 354 vs. 1399 ± 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R2 = 0.299). Conclusions: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.",
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T1 - Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity

AU - Kim, Seon Mee

AU - Leet, J.

AU - Ryu, O. H.

AU - Lee, K. W.

AU - Kim, H. Y.

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Choi, D. S.

AU - Choi, Kyung Mook

PY - 2005/11/1

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N2 - Objective: We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients. Patients and measurements: The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured. Results: Serum OPG levels (6.1 ± 1.4 vs. 5.4 ± 1.3 pmol/l, P = 0.011) and baPWV (1562 ± 354 vs. 1399 ± 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R2 = 0.299). Conclusions: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

AB - Objective: We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients. Patients and measurements: The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured. Results: Serum OPG levels (6.1 ± 1.4 vs. 5.4 ± 1.3 pmol/l, P = 0.011) and baPWV (1562 ± 354 vs. 1399 ± 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R2 = 0.299). Conclusions: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

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