Serum phosphorus as a predictor of low-grade albuminuria in a general population without evidence of chronic kidney disease

Hajeong Lee, Se Won Oh, Nam Ju Heo, Ho Jun Chin, Ki Young Na, Suhnggwon Kim, Dong Wan Chae

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Abstract

Background High levels of serum phosphorus, even within the normal range, have been associated with cardiovascular (CV) morbidity. Low-grade albuminuria (LGA) was demonstrated to be related to increased CV events in various study populations. The present study aimed to investigate the association between serum phosphorus levels and LGA in the general population. Methods We examined the individuals who had undergone health inspections. We evaluated the correlation between serum phosphorus and LGA in 8953 participants (mean age, 47.4 years) with estimated glomerular filtration rates (eGFRs) <60 mL/min/1.73m2 and urinary albumin-to-creatinine ratios (UACRs) <30 mg/g. Participants who underwent a colonoscopy were excluded. Results The mean UACR was significantly higher in the uppermost quartile group of serum phosphorus concentrations than in other quartile groups. In the multivariate regression analysis, serum phosphorus remained an independent predictor of increased UACR (B = 0.610, P < 0.001). Subgroup analyses showed that this association was maintained irrespective of age, gender, presence of hypertension or diabetes, body mass index and eGFR. Conclusions In our population-based study, higher serum phosphorus was independently related to LGA in individuals without evidence of renal dysfunction. Further investigations are warranted to clarify the precise mechanism of the association between serum phosphorus and LGA.

Original languageEnglish
Pages (from-to)2799-2806
Number of pages8
JournalNephrology Dialysis Transplantation
Volume27
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1
Externally publishedYes

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Keywords

  • general population
  • low-grade albuminuria
  • serum phosphorus concentration

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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