Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease

Ji A Seo, Nan Hee Kim, S. Y. Park, H. Y. Kim, O. H. Ryu, K. W. Lee, Juneyoung Lee, D. L. Kim, Kyung Mook Choi, Sei-Hyun Baik, D. S. Choi, Sin Gon Kim

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Abstract

Objective: Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states. We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults. Methods: One hundred and fifty-nine nondiabetic, non-alcoholic subjects (95 males and 64 females) participated in this study. Division of subjects into a NAFLD group (n = 73; 45 males and 28 females) or a normal group (n = 86; 50 males and 36 females) was based on the presence of fatty liver disease determined by sonography. Results: Serum RBP4 levels in the NAFLD group were significantly higher than those in the normal group (62.8 ± 16.0 mg/l vs. 51.7 ± 14.6 mg/l, P < 0.0001). Multiple logistic regression analysis revealed that the RBP4 level was an independent factor associated with NAFLD (P = 0.0042). In addition, serum RBP4 levels were positively correlated with serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltranspeptidase (GGT) levels. The significant association between serum RBP4 and GGT levels remained even after adjusting for age, gender, body mass index, the homeostasis model of assessment (HOMA) value and the presence of NAFLD (r = 0.3097, P = 0.0002). Conclusion: Serum RBP4 levels are significantly associated with NAFLD and liver enzymes.

Original languageEnglish
Pages (from-to)555-560
Number of pages6
JournalClinical Endocrinology
Volume68
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

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Retinol-Binding Proteins
Serum
Adipokines
Fatty Liver
Aspartate Aminotransferases
Non-alcoholic Fatty Liver Disease
Alanine Transaminase
Liver Diseases
Ultrasonography
Body Mass Index
Homeostasis
Logistic Models
Regression Analysis
Insulin
Liver
Enzymes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease. / Seo, Ji A; Kim, Nan Hee; Park, S. Y.; Kim, H. Y.; Ryu, O. H.; Lee, K. W.; Lee, Juneyoung; Kim, D. L.; Choi, Kyung Mook; Baik, Sei-Hyun; Choi, D. S.; Kim, Sin Gon.

In: Clinical Endocrinology, Vol. 68, No. 4, 01.04.2008, p. 555-560.

Research output: Contribution to journalArticle

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AU - Ryu, O. H.

AU - Lee, K. W.

AU - Lee, Juneyoung

AU - Kim, D. L.

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N2 - Objective: Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states. We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults. Methods: One hundred and fifty-nine nondiabetic, non-alcoholic subjects (95 males and 64 females) participated in this study. Division of subjects into a NAFLD group (n = 73; 45 males and 28 females) or a normal group (n = 86; 50 males and 36 females) was based on the presence of fatty liver disease determined by sonography. Results: Serum RBP4 levels in the NAFLD group were significantly higher than those in the normal group (62.8 ± 16.0 mg/l vs. 51.7 ± 14.6 mg/l, P < 0.0001). Multiple logistic regression analysis revealed that the RBP4 level was an independent factor associated with NAFLD (P = 0.0042). In addition, serum RBP4 levels were positively correlated with serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltranspeptidase (GGT) levels. The significant association between serum RBP4 and GGT levels remained even after adjusting for age, gender, body mass index, the homeostasis model of assessment (HOMA) value and the presence of NAFLD (r = 0.3097, P = 0.0002). Conclusion: Serum RBP4 levels are significantly associated with NAFLD and liver enzymes.

AB - Objective: Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states. We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults. Methods: One hundred and fifty-nine nondiabetic, non-alcoholic subjects (95 males and 64 females) participated in this study. Division of subjects into a NAFLD group (n = 73; 45 males and 28 females) or a normal group (n = 86; 50 males and 36 females) was based on the presence of fatty liver disease determined by sonography. Results: Serum RBP4 levels in the NAFLD group were significantly higher than those in the normal group (62.8 ± 16.0 mg/l vs. 51.7 ± 14.6 mg/l, P < 0.0001). Multiple logistic regression analysis revealed that the RBP4 level was an independent factor associated with NAFLD (P = 0.0042). In addition, serum RBP4 levels were positively correlated with serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltranspeptidase (GGT) levels. The significant association between serum RBP4 and GGT levels remained even after adjusting for age, gender, body mass index, the homeostasis model of assessment (HOMA) value and the presence of NAFLD (r = 0.3097, P = 0.0002). Conclusion: Serum RBP4 levels are significantly associated with NAFLD and liver enzymes.

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