Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

Qinghao Jin; Jin Woo Lee; Hari Jang; Ji Eun Choi; Dongho Lee; Jin Tae Hong; Youngsoo Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1021/acs.jnatprod.5b01106

Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

Qinghao Jin, Jin Woo Lee, Hari Jang, Ji Eun Choi, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Eight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC₅₀ values ranging from 1.9 to 15.4 μM.

Original language	English
Pages (from-to)	1548-1553
Number of pages	6
Journal	Journal of Natural Products
Volume	79
Issue number	6
DOIs	https://doi.org/10.1021/acs.jnatprod.5b01106
Publication status	Published - 2016 Jun 24

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.5b01106

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title = "Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells",

abstract = "Eight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 μM.",

author = "Qinghao Jin and Lee, {Jin Woo} and Hari Jang and Choi, {Ji Eun} and Dongho Lee and Hong, {Jin Tae} and Youngsoo Kim and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

note = "Funding Information: This research was supported by a Medical Research Center Program (MRC, 2008-0062275) through the National Research Foundation of Korea. The authors acknowledge the Korea Basic Science Institute for the NMR measurements. This work was conducted during the research year of Chungbuk National University in 2014. Publisher Copyright: {\textcopyright} 2016 The American Chemical Society and American Society of Pharmacognosy. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1021/acs.jnatprod.5b01106",

language = "English",

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AU - Jin, Qinghao

AU - Lee, Jin Woo

AU - Jang, Hari

AU - Choi, Ji Eun

AU - Lee, Dongho

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This research was supported by a Medical Research Center Program (MRC, 2008-0062275) through the National Research Foundation of Korea. The authors acknowledge the Korea Basic Science Institute for the NMR measurements. This work was conducted during the research year of Chungbuk National University in 2014. Publisher Copyright: © 2016 The American Chemical Society and American Society of Pharmacognosy. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016/6/24

Y1 - 2016/6/24

N2 - Eight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 μM.

AB - Eight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 μM.

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Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

Abstract

ASJC Scopus subject areas

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