TY - JOUR
T1 - Sesquiterpenoids from an edible plant Petasites japonicus and their promoting effects on neurite outgrowth
AU - Xu, Jing
AU - Ji, Feifei
AU - Cao, Xiangrong
AU - Ma, Jun
AU - Ohizumi, Yasushi
AU - Lee, Dongho
AU - Guo, Yuanqiang
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 21372125 ).
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Petasites japonicus (Sieb. & Zucc.) Maxim., belonging to the Compositae family, is a perennial herb and has been consumed as a wild vegetable. Our survey on the chemical composition of P. japonicus resulted in the isolation of two new and seventeen known sesquiterpenoids. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data analysis, and the absolute configurations of the new compounds were established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Among these isolates, compound 1 was a sesquiterpene carrying a chlorine atom, 2 processed a rare 7,9-secobakkenolide skeleton, and compounds 4, 11- 13, 15, 18, and 19 were obtained from this species for the first time. Most of these compounds showed promoting effects on neurite outgrowth from PC12 cells. These chemical and biological results provide a basis for further development and utilization of P. japonicus as a functional food.
AB - Petasites japonicus (Sieb. & Zucc.) Maxim., belonging to the Compositae family, is a perennial herb and has been consumed as a wild vegetable. Our survey on the chemical composition of P. japonicus resulted in the isolation of two new and seventeen known sesquiterpenoids. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data analysis, and the absolute configurations of the new compounds were established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Among these isolates, compound 1 was a sesquiterpene carrying a chlorine atom, 2 processed a rare 7,9-secobakkenolide skeleton, and compounds 4, 11- 13, 15, 18, and 19 were obtained from this species for the first time. Most of these compounds showed promoting effects on neurite outgrowth from PC12 cells. These chemical and biological results provide a basis for further development and utilization of P. japonicus as a functional food.
KW - ECD calculation
KW - Petasites japonicus
KW - Promoting effects on neurite outgrowth
KW - Sesquiterpenoids
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U2 - 10.1016/j.jff.2016.01.012
DO - 10.1016/j.jff.2016.01.012
M3 - Article
AN - SCOPUS:84962254427
VL - 22
SP - 291
EP - 299
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
ER -