Abstract
Petasites japonicus (Sieb. & Zucc.) Maxim., belonging to the Compositae family, is a perennial herb and has been consumed as a wild vegetable. Our survey on the chemical composition of P. japonicus resulted in the isolation of two new and seventeen known sesquiterpenoids. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data analysis, and the absolute configurations of the new compounds were established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Among these isolates, compound 1 was a sesquiterpene carrying a chlorine atom, 2 processed a rare 7,9-secobakkenolide skeleton, and compounds 4, 11- 13, 15, 18, and 19 were obtained from this species for the first time. Most of these compounds showed promoting effects on neurite outgrowth from PC12 cells. These chemical and biological results provide a basis for further development and utilization of P. japonicus as a functional food.
| Original language | English |
|---|---|
| Pages (from-to) | 291-299 |
| Number of pages | 9 |
| Journal | Journal of Functional Foods |
| Volume | 22 |
| DOIs | |
| Publication status | Published - 2016 Apr 1 |
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Keywords
- ECD calculation
- Petasites japonicus
- Promoting effects on neurite outgrowth
- Sesquiterpenoids
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Sesquiterpenoids from an edible plant Petasites japonicus and their promoting effects on neurite outgrowth. / Xu, Jing; Ji, Feifei; Cao, Xiangrong; Ma, Jun; Ohizumi, Yasushi; Lee, Dongho; Guo, Yuanqiang.
In: Journal of Functional Foods, Vol. 22, 01.04.2016, p. 291-299.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sesquiterpenoids from an edible plant Petasites japonicus and their promoting effects on neurite outgrowth
AU - Xu, Jing
AU - Ji, Feifei
AU - Cao, Xiangrong
AU - Ma, Jun
AU - Ohizumi, Yasushi
AU - Lee, Dongho
AU - Guo, Yuanqiang
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Petasites japonicus (Sieb. & Zucc.) Maxim., belonging to the Compositae family, is a perennial herb and has been consumed as a wild vegetable. Our survey on the chemical composition of P. japonicus resulted in the isolation of two new and seventeen known sesquiterpenoids. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data analysis, and the absolute configurations of the new compounds were established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Among these isolates, compound 1 was a sesquiterpene carrying a chlorine atom, 2 processed a rare 7,9-secobakkenolide skeleton, and compounds 4, 11- 13, 15, 18, and 19 were obtained from this species for the first time. Most of these compounds showed promoting effects on neurite outgrowth from PC12 cells. These chemical and biological results provide a basis for further development and utilization of P. japonicus as a functional food.
AB - Petasites japonicus (Sieb. & Zucc.) Maxim., belonging to the Compositae family, is a perennial herb and has been consumed as a wild vegetable. Our survey on the chemical composition of P. japonicus resulted in the isolation of two new and seventeen known sesquiterpenoids. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data analysis, and the absolute configurations of the new compounds were established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Among these isolates, compound 1 was a sesquiterpene carrying a chlorine atom, 2 processed a rare 7,9-secobakkenolide skeleton, and compounds 4, 11- 13, 15, 18, and 19 were obtained from this species for the first time. Most of these compounds showed promoting effects on neurite outgrowth from PC12 cells. These chemical and biological results provide a basis for further development and utilization of P. japonicus as a functional food.
KW - ECD calculation
KW - Petasites japonicus
KW - Promoting effects on neurite outgrowth
KW - Sesquiterpenoids
UR - http://www.scopus.com/inward/record.url?scp=84962254427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962254427&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2016.01.012
DO - 10.1016/j.jff.2016.01.012
M3 - Article
AN - SCOPUS:84962254427
VL - 22
SP - 291
EP - 299
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
ER -