Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells

Hari Jang, Jin Woo Lee, Chul Lee, Qinghao Jin, Jeong Yeon Choi, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 μM.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalArchives of Pharmacal Research
Volume39
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Asteraceae
  • Nitric oxide production inhibitor
  • Oplopane-type sesquiterpenoid
  • Tussilago farfara

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

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    Jang, H., Lee, J. W., Lee, C., Jin, Q., Choi, J. Y., Lee, D., Han, S. B., Kim, Y., Hong, J. T., Lee, M. K., & Hwang, B. Y. (2016). Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells. Archives of Pharmacal Research, 39(1), 127-132. https://doi.org/10.1007/s12272-015-0667-7