Severe osteomyelitis as a complication of Tokyo-172 BCG vaccination

Hyo Jin Kwon, Bo Hyun Chung, Byung Min Choi, Kyung Un Park, Yun Kyung Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The bacilli Calmette-Guérin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalJournal of Korean medical science
Volume27
Issue number2
DOIs
Publication statusPublished - 2012

Keywords

  • Bacilli calmette-guérin vaccination
  • Complication
  • Osteomyelitis

ASJC Scopus subject areas

  • Medicine(all)

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