Severe periodontitis is associated with insulin resistance in non-abdominal obese adults

In-Seok Song, Kyungdo Han, Yong Moon Park, Suk Ji, Sang Ho Jun, Jae Jun Ryu, Jun Beom Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Context:Wehypothesized that insulin resistance, even with normal body weight (body mass index or waist circumference), can aggravate periodontitis severity. Objective: We investigated the associations between diabetes, insulin resistance, and severe periodontitis. Design: Among 29 235 total participants, 5690 subjects aged ≤ 30 y who had periodontal disease with community periodontal index (CPI) of 3 or 4 were selected for this study. Participants: Data were derived from the 2008-2010 Korea National Health and Nutrition Examination Survey. Results: Patients diagnosed with type 2 diabetes were more likely to have severe periodontitis (CPI 4) compared with patients with normal glucose tolerance or impaired fasting glucose (P = .001). Subjects with severe periodontitis had significantly higher prevalence of abdominal obesity, serum triglycerides, and insulin resistance (P values of .012, <.001, and .003, respectively). The odds ratios (ORs) for prevalence of severe periodontitis were significantly increased from normal glucose tolerance and impaired fasting glucose (OR = 1.32; 95%confidence interval, 1.06-1.64) to type 2 diabetes (OR = 1.5; 95%CI, 1.11-2.02), after adjusting for potential confounders (P for trend = .003). The prevalence of severe periodontitis increased significantly with increasing insulin resistance (P for trend = .04) in nondiabetic individuals. Furthermore, insulin-resistant individuals with normal waist circumference showed significantly higher odds of severe periodontitis (OR = 1.47; 95%CI, 1.16-1.87) than did insulinsensitive individuals with normal waist circumference. Conclusions: Non-abdominally obese subjects with insulin resistance were more likely to have severe periodontitis. Insulin resistance can be considered an independent risk factor of periodontal disease in normal weight population defined by abdominal obesity. (J Clin Endocrinol Metab 101: 4251-4259, 2016).

Original languageEnglish
Pages (from-to)4251-4259
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume101
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

Fingerprint

Periodontitis
Insulin Resistance
Insulin
Medical problems
Waist Circumference
Odds Ratio
Glucose
Periodontal Index
Glucose Intolerance
Abdominal Obesity
Periodontal Diseases
Type 2 Diabetes Mellitus
Fasting
Ideal Body Weight
Nutrition
Nutrition Surveys
Korea
Triglycerides
Health
Body Mass Index

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Severe periodontitis is associated with insulin resistance in non-abdominal obese adults. / Song, In-Seok; Han, Kyungdo; Park, Yong Moon; Ji, Suk; Jun, Sang Ho; Ryu, Jae Jun; Park, Jun Beom.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 101, No. 11, 01.11.2016, p. 4251-4259.

Research output: Contribution to journalArticle

Song, In-Seok ; Han, Kyungdo ; Park, Yong Moon ; Ji, Suk ; Jun, Sang Ho ; Ryu, Jae Jun ; Park, Jun Beom. / Severe periodontitis is associated with insulin resistance in non-abdominal obese adults. In: Journal of Clinical Endocrinology and Metabolism. 2016 ; Vol. 101, No. 11. pp. 4251-4259.
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AU - Ryu, Jae Jun

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N2 - Context:Wehypothesized that insulin resistance, even with normal body weight (body mass index or waist circumference), can aggravate periodontitis severity. Objective: We investigated the associations between diabetes, insulin resistance, and severe periodontitis. Design: Among 29 235 total participants, 5690 subjects aged ≤ 30 y who had periodontal disease with community periodontal index (CPI) of 3 or 4 were selected for this study. Participants: Data were derived from the 2008-2010 Korea National Health and Nutrition Examination Survey. Results: Patients diagnosed with type 2 diabetes were more likely to have severe periodontitis (CPI 4) compared with patients with normal glucose tolerance or impaired fasting glucose (P = .001). Subjects with severe periodontitis had significantly higher prevalence of abdominal obesity, serum triglycerides, and insulin resistance (P values of .012, <.001, and .003, respectively). The odds ratios (ORs) for prevalence of severe periodontitis were significantly increased from normal glucose tolerance and impaired fasting glucose (OR = 1.32; 95%confidence interval, 1.06-1.64) to type 2 diabetes (OR = 1.5; 95%CI, 1.11-2.02), after adjusting for potential confounders (P for trend = .003). The prevalence of severe periodontitis increased significantly with increasing insulin resistance (P for trend = .04) in nondiabetic individuals. Furthermore, insulin-resistant individuals with normal waist circumference showed significantly higher odds of severe periodontitis (OR = 1.47; 95%CI, 1.16-1.87) than did insulinsensitive individuals with normal waist circumference. Conclusions: Non-abdominally obese subjects with insulin resistance were more likely to have severe periodontitis. Insulin resistance can be considered an independent risk factor of periodontal disease in normal weight population defined by abdominal obesity. (J Clin Endocrinol Metab 101: 4251-4259, 2016).

AB - Context:Wehypothesized that insulin resistance, even with normal body weight (body mass index or waist circumference), can aggravate periodontitis severity. Objective: We investigated the associations between diabetes, insulin resistance, and severe periodontitis. Design: Among 29 235 total participants, 5690 subjects aged ≤ 30 y who had periodontal disease with community periodontal index (CPI) of 3 or 4 were selected for this study. Participants: Data were derived from the 2008-2010 Korea National Health and Nutrition Examination Survey. Results: Patients diagnosed with type 2 diabetes were more likely to have severe periodontitis (CPI 4) compared with patients with normal glucose tolerance or impaired fasting glucose (P = .001). Subjects with severe periodontitis had significantly higher prevalence of abdominal obesity, serum triglycerides, and insulin resistance (P values of .012, <.001, and .003, respectively). The odds ratios (ORs) for prevalence of severe periodontitis were significantly increased from normal glucose tolerance and impaired fasting glucose (OR = 1.32; 95%confidence interval, 1.06-1.64) to type 2 diabetes (OR = 1.5; 95%CI, 1.11-2.02), after adjusting for potential confounders (P for trend = .003). The prevalence of severe periodontitis increased significantly with increasing insulin resistance (P for trend = .04) in nondiabetic individuals. Furthermore, insulin-resistant individuals with normal waist circumference showed significantly higher odds of severe periodontitis (OR = 1.47; 95%CI, 1.16-1.87) than did insulinsensitive individuals with normal waist circumference. Conclusions: Non-abdominally obese subjects with insulin resistance were more likely to have severe periodontitis. Insulin resistance can be considered an independent risk factor of periodontal disease in normal weight population defined by abdominal obesity. (J Clin Endocrinol Metab 101: 4251-4259, 2016).

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