Abstract
Objective: Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods: A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results: Sodium intake was significantly correlated with the obesity index (r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient -3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions: These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.
| Original language | English |
|---|---|
| Pages (from-to) | 525-530 |
| Number of pages | 6 |
| Journal | Nutrition |
| Volume | 29 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 Mar 1 |
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Keywords
- Adiposity
- Angiotensin-converting enzyme insertion/deletion polymorphism
- Gender-dependent association
- Obesity
- Sodium intake
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children. / Yang, Soo Jin; Kim, Sunyoung; Park, Hyesoon; Kim, Seon Mee; Choi, Kyung Mook; Lim, Yunsook; Lee, Myoungsook.
In: Nutrition, Vol. 29, No. 3, 01.03.2013, p. 525-530.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children
AU - Yang, Soo Jin
AU - Kim, Sunyoung
AU - Park, Hyesoon
AU - Kim, Seon Mee
AU - Choi, Kyung Mook
AU - Lim, Yunsook
AU - Lee, Myoungsook
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Objective: Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods: A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results: Sodium intake was significantly correlated with the obesity index (r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient -3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions: These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.
AB - Objective: Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods: A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results: Sodium intake was significantly correlated with the obesity index (r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient -3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions: These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.
KW - Adiposity
KW - Angiotensin-converting enzyme insertion/deletion polymorphism
KW - Gender-dependent association
KW - Obesity
KW - Sodium intake
UR - http://www.scopus.com/inward/record.url?scp=84873558814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873558814&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2012.09.001
DO - 10.1016/j.nut.2012.09.001
M3 - Article
VL - 29
SP - 525
EP - 530
JO - Nutrition
JF - Nutrition
SN - 0899-9007
IS - 3
ER -