Sex-dependent association between angiotensin-converting enzyme insertion/deletion polymorphism and obesity in relation to sodium intake in children

Soo Jin Yang, Sunyoung Kim, Hyesoon Park, Seon Mee Kim, Kyung Mook Choi, Yunsook Lim, Myoungsook Lee

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Objective: Obesity is a complex condition that is influenced by genetic and environmental factors and is associated with an increased risk for diabetes, hypertension, and cardiovascular diseases. Angiotensin-converting enzyme (ACE) is well characterized in the control of blood pressure. This study investigated whether the ACE insertion/deletion (I/D) polymorphism affects obesity in relation to sodium intake in children. Methods: A cross-sectional study was conducted in 1260 elementary schoolchildren (633 boys and 627 girls). Subjects were assessed for the degree of obesity, sodium intake, and ACE I/D genotype, and associations were evaluated between the ACE I/D polymorphism and obesity in relation to sodium intake. Results: Sodium intake was significantly correlated with the obesity index (r = 0.048, P = 0.016) and was particularly high in obese D-carrier boys compared with normal D-carrier boys. D-carrier boys did not show any association with the degree of obesity, whereas D-carrier girls with a high sodium intake exhibited a significant association (odds ratio 0.551, P = 0.042) and a negative correlation between the D allele and obesity as a continuous variable (regression coefficient -3.095, P = 0.020), showing gender-dependent associations between the ACE I/D polymorphism and obesity in relation to sodium intake. Conclusions: These findings demonstrate that the association between the ACE I/D polymorphism and obesity in relation to sodium intake is gender dependent in children.

    Original languageEnglish
    Pages (from-to)525-530
    Number of pages6
    JournalNutrition
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - 2013 Mar

    Keywords

    • Adiposity
    • Angiotensin-converting enzyme insertion/deletion polymorphism
    • Gender-dependent association
    • Obesity
    • Sodium intake

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Nutrition and Dietetics

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