Sex Difference in the Association between Metabolic Syndrome and Left Ventricular Diastolic Dysfunction

Hack Lyoung Kim, Myung A. Kim, Sohee Oh, Mina Kim, Seong-Mi Park, Hyun Ju Yoon, Mi Seung Shin, Kyung Soon Hong, Gil Ja Shin, Wan Joo Shim

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8 Citations (Scopus)


Background: Sex-related differences in the influence of metabolic syndrome (MetS) on various cardiovascular diseases have been suggested. The aim of this study was to investigate the effect of sex on the association between MetS and left ventricular (LV) diastolic dysfunction in patients with suspected coronary artery disease (CAD). Methods: Two hundred ten patients (105 men and age-matched 105 women; mean age: 56.5 ± 10.9 years) undergoing elective coronary angiography for the evaluation of CAD were studied. MetS was defined according to the International Diabetes Federation criteria. LV diastolic function was assessed using transthoracic echocardiography. Results: The incidence of MetS was 23.8% in men and 14.3% in women (P = 0.079). The incidence of LV diastolic dysfunction was significantly different by MetS in women, but not in men. In multiple linear regression analyses, the number of MetS components was independently associated with septal e′ velocity, E/e′, and left atrial (LA) diameter in women (P < 0.05 for each). In men, the number of MetS components was associated with only LA size in this analysis. As the number of components of MetS increased, septal e′ velocity decreased proportionally in women (P < 0.001), but not in men (P = 0.117). Conclusions: Among middle-aged and elderly Korean patients at high risk of CAD, the impact of MetS on LV diastolic dysfunction was more pronounced in women than in men. This suggests the important role of sex hormonal effects in the development of LV diastolic dysfunction in relation to MetS in this population.

Original languageEnglish
Pages (from-to)507-512
Number of pages6
JournalMetabolic Syndrome and Related Disorders
Issue number10
Publication statusPublished - 2016 Dec 1



  • coronary artery disease
  • diastolic function
  • metabolic syndrome
  • sex

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Kim, H. L., Kim, M. A., Oh, S., Kim, M., Park, S-M., Yoon, H. J., Shin, M. S., Hong, K. S., Shin, G. J., & Shim, W. J. (2016). Sex Difference in the Association between Metabolic Syndrome and Left Ventricular Diastolic Dysfunction. Metabolic Syndrome and Related Disorders, 14(10), 507-512.