Sex differences in hippocampal neuronal sensitization by nicotine in M. gerbils

Young Na Hur, Joon Lee, Seung Chan Sohn, Chung Gil Won, Hyung Ha Lee, Dong-Hun Kim, Sang-Hyun Choi, Kyung-Ho Shin, Boe Gwun Chun

Research output: Contribution to journalArticle

Abstract

We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5 mg/kg: NT-0.5) slightly reduced ePSA in males but markedly augmented that in females. Acute NT (5.0 mg/kg) markedly increased the ePSA in all gerbils. Unlike acute NT-0.5, repeated NT-0.5 injection (twice a day for 7 days) significantly increased the ePSA in males and slightly affected the NT-0.5 effect in females. The Cx36 and Cx43 expression levels as well as Cx expressing neuronal populations were significantly increased by repeated NT-0.5 in in both male and female gerbils, and particularly, Cx43 expression was somewhat prominent in females. These results demonstrated a sex difference with respect to the nicotine effect on hippocampal bisynaptic excitability, irrelevant to connexin expression.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalKorean Journal of Physiology and Pharmacology
Volume17
Issue number5
DOIs
Publication statusPublished - 2013 Oct 1

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Gerbillinae
Sex Characteristics
Connexins
Nicotine
Connexin 43
Population
Hippocampus
N-methyl-nicotine
Injections

Keywords

  • Connexin
  • Evoked population spike
  • Hippocampus
  • Nicotine
  • Sex difference

ASJC Scopus subject areas

  • Pharmacology
  • Physiology

Cite this

Sex differences in hippocampal neuronal sensitization by nicotine in M. gerbils. / Hur, Young Na; Lee, Joon; Sohn, Seung Chan; Won, Chung Gil; Lee, Hyung Ha; Kim, Dong-Hun; Choi, Sang-Hyun; Shin, Kyung-Ho; Chun, Boe Gwun.

In: Korean Journal of Physiology and Pharmacology, Vol. 17, No. 5, 01.10.2013, p. 405-409.

Research output: Contribution to journalArticle

Hur, Young Na ; Lee, Joon ; Sohn, Seung Chan ; Won, Chung Gil ; Lee, Hyung Ha ; Kim, Dong-Hun ; Choi, Sang-Hyun ; Shin, Kyung-Ho ; Chun, Boe Gwun. / Sex differences in hippocampal neuronal sensitization by nicotine in M. gerbils. In: Korean Journal of Physiology and Pharmacology. 2013 ; Vol. 17, No. 5. pp. 405-409.
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