Shape-memory effect by specific biodegradable polymer blending for biomedical applications

Kook Jin Cha, Eugene Lih, Jiyeon Choi, Yoon Ki Joung, Dong Jun Ahn, Dong Keun Han

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.

Original languageEnglish
Pages (from-to)667-678
Number of pages12
JournalMacromolecular Bioscience
Volume14
Issue number5
DOIs
Publication statusPublished - 2014 May
Externally publishedYes

Keywords

  • biodegradable polymers
  • biomedical applications
  • glass transition temperature
  • polymer blends
  • shape memory polymers

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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