Shape-memory effect by specific biodegradable polymer blending for biomedical applications

Kook Jin Cha; Eugene Lih; Jiyeon Choi; Yoon Ki Joung; Dong Jun Ahn; Dong Keun Han

doi:10.1002/mabi.201300481

Shape-memory effect by specific biodegradable polymer blending for biomedical applications

Kook Jin Cha, Eugene Lih, Jiyeon Choi, Yoon Ki Joung, Dong Jun Ahn, Dong Keun Han

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.

Original language	English
Pages (from-to)	667-678
Number of pages	12
Journal	Macromolecular Bioscience
Volume	14
Issue number	5
DOIs	https://doi.org/10.1002/mabi.201300481
Publication status	Published - 2014 May
Externally published	Yes

Keywords

biodegradable polymers
biomedical applications
glass transition temperature
polymer blends
shape memory polymers

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

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10.1002/mabi.201300481

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title = "Shape-memory effect by specific biodegradable polymer blending for biomedical applications",

abstract = "Specific biodegradable polymers having shape-memory properties through {"}polymer-blend{"} method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.",

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author = "Cha, {Kook Jin} and Eugene Lih and Jiyeon Choi and Joung, {Yoon Ki} and Ahn, {Dong Jun} and Han, {Dong Keun}",

year = "2014",

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doi = "10.1002/mabi.201300481",

language = "English",

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AU - Cha, Kook Jin

AU - Lih, Eugene

AU - Choi, Jiyeon

AU - Joung, Yoon Ki

AU - Ahn, Dong Jun

AU - Han, Dong Keun

PY - 2014/5

Y1 - 2014/5

N2 - Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.

AB - Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.

KW - biodegradable polymers

KW - biomedical applications

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Shape-memory effect by specific biodegradable polymer blending for biomedical applications

Abstract

Keywords

ASJC Scopus subject areas

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