Shape-memory effect by specific biodegradable polymer blending for biomedical applications

Kook Jin Cha, Eugene Lih, Jiyeon Choi, Yoon Ki Joung, Dong June Ahn, Dong Keun Han

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.

Original languageEnglish
Pages (from-to)667-678
Number of pages12
JournalMacromolecular Bioscience
Volume14
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

Fingerprint

Biodegradable polymers
Shape memory effect
Polymers
Recovery
Blood
Polyglactin 910
Stents
Transition Temperature
Dynamic mechanical analysis
Polymer blends
Chloroform
Chlorine compounds
Body Temperature
Biocompatibility
Glass
Blood Vessels
Casting
Equipment and Supplies
Temperature
poly(lactide)

Keywords

  • biodegradable polymers
  • biomedical applications
  • glass transition temperature
  • polymer blends
  • shape memory polymers

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Shape-memory effect by specific biodegradable polymer blending for biomedical applications. / Cha, Kook Jin; Lih, Eugene; Choi, Jiyeon; Joung, Yoon Ki; Ahn, Dong June; Han, Dong Keun.

In: Macromolecular Bioscience, Vol. 14, No. 5, 01.01.2014, p. 667-678.

Research output: Contribution to journalArticle

Cha, Kook Jin ; Lih, Eugene ; Choi, Jiyeon ; Joung, Yoon Ki ; Ahn, Dong June ; Han, Dong Keun. / Shape-memory effect by specific biodegradable polymer blending for biomedical applications. In: Macromolecular Bioscience. 2014 ; Vol. 14, No. 5. pp. 667-678.
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