Abstract
Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.
| Original language | English |
|---|---|
| Pages (from-to) | 667-678 |
| Number of pages | 12 |
| Journal | Macromolecular Bioscience |
| Volume | 14 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
| Externally published | Yes |
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Keywords
- biodegradable polymers
- biomedical applications
- glass transition temperature
- polymer blends
- shape memory polymers
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry
Cite this
Shape-memory effect by specific biodegradable polymer blending for biomedical applications. / Cha, Kook Jin; Lih, Eugene; Choi, Jiyeon; Joung, Yoon Ki; Ahn, Dong June; Han, Dong Keun.
In: Macromolecular Bioscience, Vol. 14, No. 5, 01.01.2014, p. 667-678.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Shape-memory effect by specific biodegradable polymer blending for biomedical applications
AU - Cha, Kook Jin
AU - Lih, Eugene
AU - Choi, Jiyeon
AU - Joung, Yoon Ki
AU - Ahn, Dong June
AU - Han, Dong Keun
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.
AB - Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.
KW - biodegradable polymers
KW - biomedical applications
KW - glass transition temperature
KW - polymer blends
KW - shape memory polymers
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U2 - 10.1002/mabi.201300481
DO - 10.1002/mabi.201300481
M3 - Article
VL - 14
SP - 667
EP - 678
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
SN - 1616-5187
IS - 5
ER -