Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin

Jung Soon Hwang, Hai Chon Lee, Sang Cheul Oh, Dae Hee Lee, Ki Han Kwon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In this study, we showed the ability of representative shogaol, which as a major component of ginger, to overcome TRAIL resistance by increasing apoptosis in colon cancer cells. Shogaol increased death receptor 5 (DR5) levels. Furthermore, shogaol decreased the expression level of antiapoptotic proteins (survivin and Bcl-2) and increased pro-apoptotic protein, Bax. Shogaol treatment induced apoptosis and a robust reduction in the levels of the antiapoptotic protein survivin but did not affect the levels of many other apoptosis regulators. Moreover, knockdown of survivin sensitized colon cancer cells to resistant of TRAIL-induced apoptosis. Therefore, we showed the functions of shogaol as a sensitizing agent to induce cell death of TRAIL-resistant colon cancer cells. This study gives rise to the possibility of applying shogaol as an antitumor agent that can be used for the purpose of combination treatment with TRAIL in TRAIL-resistant colon tumor therapy.

Original languageEnglish
Pages (from-to)8819-8829
Number of pages11
JournalTumor Biology
Volume36
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

Keywords

  • Apoptosis
  • Death receptor 5 (DR5)
  • Shogaol
  • Survivin
  • Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin'. Together they form a unique fingerprint.

  • Cite this