Short communication

No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and post-traumatic stress disorder

Heon-Jeong Lee, Rhee H. Kang, Se W. Lim, Jong W. Paik, Myoung J. Choi, Min-Soo Lee

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Post-traumatic stress disorder (PTSD) is a chronic anxiety disorder that follows exposure to traumatic events. The etiology of PTSD is unknown, although exposure to a traumatic event constitutes a necessary but not sufficient factor. Recent studies have demonstrated that the brain-derived neurotrophic factor (BDNF) is related to stress-related psychiatric conditions. In this study, therefore, the genotype and allele frequencies of the BDNF gene Val66Met polymorphism were analyzed in 106 PTSD patients and 161 unrelated healthy controls using a case-control design. The genotype and allele frequencies for the BDNF gene polymorphism did not differ between the two groups. These findings suggest that the BDNF polymorphism investigated herein does not play a major role in the susceptibility to PTSD at least in the Korean population. Further studies designed to explore the relationship between genetic variations of BDNF and the incidence of PTSD in a larger population may be warranted.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalStress and Health
Volume22
Issue number2
DOIs
Publication statusPublished - 2006 May 12

Fingerprint

Brain-Derived Neurotrophic Factor
Post-Traumatic Stress Disorders
Communication
Genes
Gene Frequency
Genotype
Anxiety Disorders
Population
Psychiatry
Incidence

Keywords

  • Brain-derived neurotrophic factor
  • Polymorphism
  • PTSD

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Short communication : No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and post-traumatic stress disorder. / Lee, Heon-Jeong; Kang, Rhee H.; Lim, Se W.; Paik, Jong W.; Choi, Myoung J.; Lee, Min-Soo.

In: Stress and Health, Vol. 22, No. 2, 12.05.2006, p. 115-119.

Research output: Contribution to journalArticle

Lee, Heon-Jeong ; Kang, Rhee H. ; Lim, Se W. ; Paik, Jong W. ; Choi, Myoung J. ; Lee, Min-Soo. / Short communication : No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and post-traumatic stress disorder. In: Stress and Health. 2006 ; Vol. 22, No. 2. pp. 115-119.
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