Short report: Emergence of new alleles of the MSP-3́ gene in Plasmodium vivax isolates from Korea

Deok Hwa Nam, Jun Seo Oh, Myoung Hyun Nam, Hae Chul Park, Chae Seung Lim, Won Ja Lee, Jetsumon Sattabongkot, Terry A. Klein, Francisco J. Ayala

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Nucleotide sequence analysis of the Plasmodium vivax PvMSP-3α gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3α alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006-2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains.

Original languageEnglish
Pages (from-to)522-524
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume82
Issue number4
DOIs
Publication statusPublished - 2010 Apr

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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