Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus

Joong Jean Park, Heung Kyung Lee, Min Woo Shin, Sung Jin Kim, Seung Yeon Noh, Jin Shin, Woo Sung Yu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) is an orexigenic and hypothermic peptide. To understand its role in hypothermic conditions, male rats were placed in a 24°C or 4°C air chamber for 1.5 h. The expression of c-Fos protein, and NPY mRNA and protein, was analyzed in the hypothalamus 1 h-2 h later. The cold treatment increased the number of c-Fos-immunoreactive cells in the paraventricular hypothalamic nucleus (PVN) and arcuate nucleus (ARC). At the same time it decreased the density of NPY-immunoreactive components in the PVN, dorsomedial hypothalamic nucleus and ARC, as well as of NPY transcripts in the PVN and ARC. No colocalization of c-Fos with NPY was detected. These results suggest that short-term cold exposure should reduce indirectly NPY production in some hypothalamic nuclei to facilitate thermogenesis without inducing feeding behavior.

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalMolecules and Cells
Volume23
Issue number1
Publication statusPublished - 2007 Feb 1

Fingerprint

Neuropeptide Y
Hypothalamus
Arcuate Nucleus of Hypothalamus
Paraventricular Hypothalamic Nucleus
Dorsomedial Hypothalamic Nucleus
Proto-Oncogene Proteins c-fos
Thermogenesis
Feeding Behavior
Air
Messenger RNA
Peptides
Proteins

Keywords

  • Arcuate nucleus
  • C-Fos
  • Hypothalamus
  • Hypothermia
  • Neuropeptide Y

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Park, J. J., Lee, H. K., Shin, M. W., Kim, S. J., Noh, S. Y., Shin, J., & Yu, W. S. (2007). Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus. Molecules and Cells, 23(1), 88-93.

Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus. / Park, Joong Jean; Lee, Heung Kyung; Shin, Min Woo; Kim, Sung Jin; Noh, Seung Yeon; Shin, Jin; Yu, Woo Sung.

In: Molecules and Cells, Vol. 23, No. 1, 01.02.2007, p. 88-93.

Research output: Contribution to journalArticle

Park, JJ, Lee, HK, Shin, MW, Kim, SJ, Noh, SY, Shin, J & Yu, WS 2007, 'Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus', Molecules and Cells, vol. 23, no. 1, pp. 88-93.
Park, Joong Jean ; Lee, Heung Kyung ; Shin, Min Woo ; Kim, Sung Jin ; Noh, Seung Yeon ; Shin, Jin ; Yu, Woo Sung. / Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus. In: Molecules and Cells. 2007 ; Vol. 23, No. 1. pp. 88-93.
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