Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus

Joong Jean Park, Heung Kyung Lee, Min Woo Shin, Sung Jin Kim, Seung Yeon Noh, Jin Shin, Woo Sung Yu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Neuropeptide Y (NPY) is an orexigenic and hypothermic peptide. To understand its role in hypothermic conditions, male rats were placed in a 24°C or 4°C air chamber for 1.5 h. The expression of c-Fos protein, and NPY mRNA and protein, was analyzed in the hypothalamus 1 h-2 h later. The cold treatment increased the number of c-Fos-immunoreactive cells in the paraventricular hypothalamic nucleus (PVN) and arcuate nucleus (ARC). At the same time it decreased the density of NPY-immunoreactive components in the PVN, dorsomedial hypothalamic nucleus and ARC, as well as of NPY transcripts in the PVN and ARC. No colocalization of c-Fos with NPY was detected. These results suggest that short-term cold exposure should reduce indirectly NPY production in some hypothalamic nuclei to facilitate thermogenesis without inducing feeding behavior.

Original languageEnglish
Pages (from-to)88-93
Number of pages6
JournalMolecules and cells
Volume23
Issue number1
Publication statusPublished - 2007 Feb

Keywords

  • Arcuate nucleus
  • C-Fos
  • Hypothalamus
  • Hypothermia
  • Neuropeptide Y

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Park, J. J., Lee, H. K., Shin, M. W., Kim, S. J., Noh, S. Y., Shin, J., & Yu, W. S. (2007). Short-term cold exposure may cause a local decrease of neuropeptide Y in the rat hypothalamus. Molecules and cells, 23(1), 88-93.