Abstract
Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm3) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal–Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.
| Original language | English |
|---|---|
| Pages (from-to) | 397-405 |
| Number of pages | 9 |
| Journal | Current Eye Research |
| Volume | 43 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2018 Mar 4 |
Fingerprint
Keywords
- Glaucoma
- magnetic resonance imaging
- optic nerve head
- optic-disk cup volume
- retinal nerve fiber layer thickness
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI : a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy. / Lee, Jong Yeon; Kwon, Hyo Jeong; Park, Su Jin; Yoo, Chungkwon; Kim, Yong Yeon; Kim, Eung Yeop.
In: Current Eye Research, Vol. 43, No. 3, 04.03.2018, p. 397-405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI
T2 - a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy
AU - Lee, Jong Yeon
AU - Kwon, Hyo Jeong
AU - Park, Su Jin
AU - Yoo, Chungkwon
AU - Kim, Yong Yeon
AU - Kim, Eung Yeop
PY - 2018/3/4
Y1 - 2018/3/4
N2 - Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm3) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal–Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.
AB - Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm3) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal–Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.
KW - Glaucoma
KW - magnetic resonance imaging
KW - optic nerve head
KW - optic-disk cup volume
KW - retinal nerve fiber layer thickness
UR - http://www.scopus.com/inward/record.url?scp=85033683089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033683089&partnerID=8YFLogxK
U2 - 10.1080/02713683.2017.1399426
DO - 10.1080/02713683.2017.1399426
M3 - Article
C2 - 29120259
AN - SCOPUS:85033683089
VL - 43
SP - 397
EP - 405
JO - Current Eye Research
JF - Current Eye Research
SN - 0271-3683
IS - 3
ER -