Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI: a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy

Jong Yeon Lee, Hyo Jeong Kwon, Su Jin Park, Chungkwon Yoo, Yong Yeon Kim, Eung Yeop Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm3) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal–Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalCurrent Eye Research
Volume43
Issue number3
DOIs
Publication statusPublished - 2018 Mar 4

Fingerprint

Optic Nerve Diseases
Optic Disk
Neuroimaging
Magnetic Resonance Imaging
Open Angle Glaucoma
Optical Coherence Tomography
Chi-Square Distribution
Nerve Fibers
Glaucoma

Keywords

  • Glaucoma
  • magnetic resonance imaging
  • optic nerve head
  • optic-disk cup volume
  • retinal nerve fiber layer thickness

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI : a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy. / Lee, Jong Yeon; Kwon, Hyo Jeong; Park, Su Jin; Yoo, Chungkwon; Kim, Yong Yeon; Kim, Eung Yeop.

In: Current Eye Research, Vol. 43, No. 3, 04.03.2018, p. 397-405.

Research output: Contribution to journalArticle

@article{bbb149e419e34c9a8952e7cadecba3a0,
title = "Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI: a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy",
abstract = "Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm3) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal–Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3{\%}) exhibited an SA in the ONH, whereas it was observed in 5 (16.1{\%}) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.",
keywords = "Glaucoma, magnetic resonance imaging, optic nerve head, optic-disk cup volume, retinal nerve fiber layer thickness",
author = "Lee, {Jong Yeon} and Kwon, {Hyo Jeong} and Park, {Su Jin} and Chungkwon Yoo and Kim, {Yong Yeon} and Kim, {Eung Yeop}",
year = "2018",
month = "3",
day = "4",
doi = "10.1080/02713683.2017.1399426",
language = "English",
volume = "43",
pages = "397--405",
journal = "Current Eye Research",
issn = "0271-3683",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI

T2 - a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy

AU - Lee, Jong Yeon

AU - Kwon, Hyo Jeong

AU - Park, Su Jin

AU - Yoo, Chungkwon

AU - Kim, Yong Yeon

AU - Kim, Eung Yeop

PY - 2018/3/4

Y1 - 2018/3/4

N2 - Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm3) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal–Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.

AB - Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm3) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal–Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.

KW - Glaucoma

KW - magnetic resonance imaging

KW - optic nerve head

KW - optic-disk cup volume

KW - retinal nerve fiber layer thickness

UR - http://www.scopus.com/inward/record.url?scp=85033683089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033683089&partnerID=8YFLogxK

U2 - 10.1080/02713683.2017.1399426

DO - 10.1080/02713683.2017.1399426

M3 - Article

C2 - 29120259

AN - SCOPUS:85033683089

VL - 43

SP - 397

EP - 405

JO - Current Eye Research

JF - Current Eye Research

SN - 0271-3683

IS - 3

ER -