Signaling role of fructose mediated by FINS1/FBP in Arabidopsis thaliana

Young Hee Cho, Sang-Dong Yoo

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Sugars are evolutionarily conserved signaling molecules that regulate the growth and development of both unicellular and multicellular organisms. As sugar-producing photosynthetic organisms, plants utilize glucose as one of their major signaling molecules. However, the details of other sugar signaling molecules and their regulatory factors have remained elusive, due to the complexity of the metabolite and hormone interactions that control physiological and developmental programs in plants. We combined information from a gain-of-function cell-based screen and a loss-of-function reverse-genetic analysis to demonstrate that fructose acts as a signaling molecule in Arabidopsis thaliana. Fructose signaling induced seedling developmental arrest and interacted with plant stress hormone signaling in a manner similar to that of glucose. For fructose signaling responses, the plant glucose sensor HEXOKINASE1 (HXK1) was dispensable, while FRUCTOSE INSENSITIVE1 (FINS1), a putative FRUCTOSE-1,6-BISPHOSPHATASE, played a crucial role. Interestingly, FINS1 function in fructose signaling appeared to be independent of its catalytic activity in sugar metabolism. Genetic analysis further indicated that FINS1-dependent fructose signaling may act downstream of the abscisic acid pathway, in spite of the fact that HXK1-dependent glucose signaling works upstream of hormone synthesis. Our findings revealed that multiple layers of controls by fructose, glucose, and abscisic acid finely tune the plant autotrophic transition and modulate early seedling establishment after seed germination.

Original languageEnglish
Article numbere1001263
JournalPLoS Genetics
Volume7
Issue number1
DOIs
Publication statusPublished - 2011 Feb 15
Externally publishedYes

Fingerprint

Fructose
Arabidopsis
fructose
Arabidopsis thaliana
glucose
Glucose
sugar
sugars
Abscisic Acid
hormone
abscisic acid
hormones
Seedlings
genetic analysis
genetic techniques and protocols
Hormones
Reverse Genetics
Plant Growth Regulators
seedlings
plant stress

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Signaling role of fructose mediated by FINS1/FBP in Arabidopsis thaliana. / Cho, Young Hee; Yoo, Sang-Dong.

In: PLoS Genetics, Vol. 7, No. 1, e1001263, 15.02.2011.

Research output: Contribution to journalArticle

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