Significance of decreasing rate of HIV and HBV co-infection in a nationwide Korean HIV/AIDS cohort

Yoonjung Kim, Shin Woo Kim, Ki Tae Kwon, Hyun Ha Chang, Yoonhee Jun, Jang Wook Sohn, Dae Won Park, Joon Young Song, Jun Yong Choi, Hyo Youl Kim, June Myung Kim, Bo Youl Choi, Yunsu Choi, Mee Kyung Kee, Myeong Su Yoo, Jung Gyu Lee

    Research output: Contribution to journalArticlepeer-review

    Abstract

    From December 2006 to December 2016, 1093 human immunodeficiency virus (HIV) individuals < 70 years enrolled in Korea human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) cohort were analyzed to investigate the prevalence of HIV/HBV co-infection rate and hepatitis B virus surface antibody (HBsAb) positive rate based on birth year. The HBV co-infection prevalence rate was the highest (8.8%) in patients born between 1960 and 1964 and the lowest (0%) among those born between 1995 and 1999. A decreasing linear trend of HBV co-infection rate was observed according to the 5-year interval changes. HBsAb-positive rate was only 58.1% in our study. The national HBV vaccination programs have effectively lowered the HBV co-infection rate in HIV population. However, it is identified that the HIV population has low HBsAb positive rate. Further evidences supporting efficacy of booster immunization for HBsAb negative HIV patients are required and efforts should be made to increase HBsAb positive rates among HIV patients to prevent horizontal transmission.

    Original languageEnglish
    Article numbere7
    JournalJournal of Korean medical science
    Volume35
    Issue number3
    DOIs
    Publication statusPublished - 2020 Jan 20

    Keywords

    • Co-infection
    • HIV infection
    • Hepatitis B virus
    • National cohort
    • Vaccination

    ASJC Scopus subject areas

    • Medicine(all)

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