Significance of sleep stability using cardiopulmonary coupling in sleep disordered breathing

Min Young Seo, Sun Jin Hwang, Kuk Jin Nam, Seung Hoon Lee

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to assess the sleep quality and sleep stability according to the severity of obstructive sleep apnea (OSA) by using questionnaires and cardiopulmonary coupling (CPC) analysis. Methods: Two hundred and twenty-one adults were evaluated using subjective sleep questionnaires, CPC parameters, and respiratory parameters measured during full-night polysomnography. We measured the differences in the CPC parameters of each OSA group and the correlation between the apnea–hypopnea index (AHI) and CPC parameters. Results: AHI and CPC parameters were not associated with sleep questionnaires. AHI is negatively correlated with high frequency coupling (HFC, r = −0.725, P < 0.001) and very low frequency coupling (VLFC, r = −0.475, P < 0.001), but it is positively correlated with low frequency coupling (LFC, r = 0.786, P < 0.001) and narrow- and broadband-elevated low frequency coupling (e-LFCNB and e-LFCBB; r = 0.522, P < 0.001 and r = 0.668, P < 0.001, respectively). We also found similar results regarding the correlation between the arousal index and CPC parameters. In addition, there were significant differences in HFC, LFC, VLFC, e-LFCNB, and e-LFCBB (all P < 0.001) between the severe OSA group and all other groups. Conclusion: We found that CPC parameters significantly correlated with AHI. In addition, sleep stability-related parameters differ significantly based on OSA severity, and apneic parameters in the severe OSA group are significantly different from those in the other groups. Level of Evidence: 4 Laryngoscope, 2019.

Original languageEnglish
JournalLaryngoscope
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Sleep Apnea Syndromes
Obstructive Sleep Apnea
Sleep
Laryngoscopes
Polysomnography
Arousal
Surveys and Questionnaires

Keywords

  • cardiopulmonary coupling
  • Obstructive sleep apnea
  • polysomnography
  • sleep quality
  • subjective sleep questionnaires

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Significance of sleep stability using cardiopulmonary coupling in sleep disordered breathing. / Seo, Min Young; Hwang, Sun Jin; Nam, Kuk Jin; Lee, Seung Hoon.

In: Laryngoscope, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Objectives: The aim of this study was to assess the sleep quality and sleep stability according to the severity of obstructive sleep apnea (OSA) by using questionnaires and cardiopulmonary coupling (CPC) analysis. Methods: Two hundred and twenty-one adults were evaluated using subjective sleep questionnaires, CPC parameters, and respiratory parameters measured during full-night polysomnography. We measured the differences in the CPC parameters of each OSA group and the correlation between the apnea–hypopnea index (AHI) and CPC parameters. Results: AHI and CPC parameters were not associated with sleep questionnaires. AHI is negatively correlated with high frequency coupling (HFC, r = −0.725, P < 0.001) and very low frequency coupling (VLFC, r = −0.475, P < 0.001), but it is positively correlated with low frequency coupling (LFC, r = 0.786, P < 0.001) and narrow- and broadband-elevated low frequency coupling (e-LFCNB and e-LFCBB; r = 0.522, P < 0.001 and r = 0.668, P < 0.001, respectively). We also found similar results regarding the correlation between the arousal index and CPC parameters. In addition, there were significant differences in HFC, LFC, VLFC, e-LFCNB, and e-LFCBB (all P < 0.001) between the severe OSA group and all other groups. Conclusion: We found that CPC parameters significantly correlated with AHI. In addition, sleep stability-related parameters differ significantly based on OSA severity, and apneic parameters in the severe OSA group are significantly different from those in the other groups. Level of Evidence: 4 Laryngoscope, 2019.",
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