Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1

Sunghee Lee; J. David Curb; Takashi Kadowaki; Rhobert W. Evans; Katsuyuki Miura; Tomoko Takamiya; Chol Shin; Aiman El-Saed; Jina Choo; Akira Fujiyoshi; Teruo Otake; Sayaka Kadowaki; Todd Seto; Kamal Masaki; Daniel Edmundowicz; Hirotsugu Ueshima; Lewis H. Kuller; Akira Sekikawa

doi:10.1017/S0007114511003199

Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1

Sunghee Lee, J. David Curb, Takashi Kadowaki, Rhobert W. Evans, Katsuyuki Miura, Tomoko Takamiya, Chol Shin, Aiman El-Saed, Jina Choo, Akira Fujiyoshi, Teruo Otake, Sayaka Kadowaki, Todd Seto, Kamal Masaki, Daniel Edmundowicz, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.

Original language	English
Pages (from-to)	567-572
Number of pages	6
Journal	British Journal of Nutrition
Volume	107
Issue number	4
DOIs	https://doi.org/10.1017/S0007114511003199
Publication status	Published - 2012 Feb 28

Keywords

Fatty acids
Linoleic acid
Plasminogen activator inhibitor-1

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1017/S0007114511003199

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Lee, S., Curb, J. D., Kadowaki, T., Evans, R. W., Miura, K., Takamiya, T., Shin, C., El-Saed, A., Choo, J., Fujiyoshi, A., Otake, T., Kadowaki, S., Seto, T., Masaki, K., Edmundowicz, D., Ueshima, H., Kuller, L. H., & Sekikawa, A. (2012). Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. British Journal of Nutrition, 107(4), 567-572. https://doi.org/10.1017/S0007114511003199

Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. / Lee, Sunghee; Curb, J. David; Kadowaki, Takashi; Evans, Rhobert W.; Miura, Katsuyuki; Takamiya, Tomoko; Shin, Chol; El-Saed, Aiman; Choo, Jina; Fujiyoshi, Akira; Otake, Teruo; Kadowaki, Sayaka; Seto, Todd; Masaki, Kamal; Edmundowicz, Daniel; Ueshima, Hirotsugu; Kuller, Lewis H.; Sekikawa, Akira.

In: British Journal of Nutrition, Vol. 107, No. 4, 28.02.2012, p. 567-572.

Research output: Contribution to journal › Article › peer-review

Lee, S, Curb, JD, Kadowaki, T, Evans, RW, Miura, K, Takamiya, T, Shin, C, El-Saed, A, Choo, J, Fujiyoshi, A, Otake, T, Kadowaki, S, Seto, T, Masaki, K, Edmundowicz, D, Ueshima, H, Kuller, LH & Sekikawa, A 2012, 'Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1', British Journal of Nutrition, vol. 107, no. 4, pp. 567-572. https://doi.org/10.1017/S0007114511003199

Lee, Sunghee ; Curb, J. David ; Kadowaki, Takashi ; Evans, Rhobert W. ; Miura, Katsuyuki ; Takamiya, Tomoko ; Shin, Chol ; El-Saed, Aiman ; Choo, Jina ; Fujiyoshi, Akira ; Otake, Teruo ; Kadowaki, Sayaka ; Seto, Todd ; Masaki, Kamal ; Edmundowicz, Daniel ; Ueshima, Hirotsugu ; Kuller, Lewis H. ; Sekikawa, Akira. / Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. In: British Journal of Nutrition. 2012 ; Vol. 107, No. 4. pp. 567-572.

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abstract = "Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.",

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