TY - JOUR
T1 - Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1
AU - Lee, Sunghee
AU - Curb, J. David
AU - Kadowaki, Takashi
AU - Evans, Rhobert W.
AU - Miura, Katsuyuki
AU - Takamiya, Tomoko
AU - Shin, Chol
AU - El-Saed, Aiman
AU - Choo, Jina
AU - Fujiyoshi, Akira
AU - Otake, Teruo
AU - Kadowaki, Sayaka
AU - Seto, Todd
AU - Masaki, Kamal
AU - Edmundowicz, Daniel
AU - Ueshima, Hirotsugu
AU - Kuller, Lewis H.
AU - Sekikawa, Akira
PY - 2012/2/28
Y1 - 2012/2/28
N2 - Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.
AB - Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.
KW - Fatty acids
KW - Linoleic acid
KW - Plasminogen activator inhibitor-1
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U2 - 10.1017/S0007114511003199
DO - 10.1017/S0007114511003199
M3 - Article
C2 - 21846428
AN - SCOPUS:84856748913
VL - 107
SP - 567
EP - 572
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 4
ER -