Silica-chitosan hybrid coating on Ti for controlled release of growth factors

Shin Hee Jun, Eun Jung Lee, Hyoun Ee Kim, Jun Hyeog Jang, Young Hag Koh

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


A hybrid material composed of a silica xerogel and chitosan was coated on Ti for the delivery of growth-factors. Fibroblast growth factor (FGF) and green fluorescence protein were incorporated into the coatings for hard tissue engineering. Silica was chosen as a coating material because of its high surface area as well as its good bioactivity. Chitosan provides mechanical stability and contributes to the control of the release rate of the growth factors. When the chitosan composition was 30% or more, the hybrid coating was stable physically and mechanically. The release of the growth-factors, observed in phosphate buffer solution at 37°C, was strongly dependent on the coating material. The hybrid coating containing FGF showed significantly improved osteoblast cell responses compared to the pure xerogel coating with FGF or the hybrid coating without FGF. These results indicate that the hybrid coating is potentially very useful in enhancing the bioactivity of metallic implants by delivering growth-factors in a controlled manner.

Original languageEnglish
Pages (from-to)2757-2764
Number of pages8
JournalJournal of Materials Science: Materials in Medicine
Issue number12
Publication statusPublished - 2011 Dec

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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