Silica coated gold nanorods for imaging and photo-thermal therapy of cancer cells

Sudipta Mallick, In Cheol Sun, Kwang Meyung Kim, Dong Kee Yi

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Due to their efficient conversion of absorbed light energy to heat gold nanorods have been proved to be an amazing tool for minimally invasive photo-thermal cancer therapy. The present in vitro study demonstrates the ability of silica coated Au nanorods to function as a dual probe for cancer-cell therapy and imaging without any toxic side-effects. HeLa cells were incubated with silica coated Au nanorods and imaged inside the cell just after 1 hour of incubation by a dark field set up due to strong surface enhanced Raman scattering. To induce hyperthermia, silica coated Au nanorod incubated HeLa cells were illuminated with a diode laser (671 nm, 200 mW, 10 min). Cell destruction was observed even at a very low dose of nanorods, whereas none was observed in the absence of nanorods. Silica coated Au nanorods thus offer a promising, novel class of selective photo-thermal agents for cancer therapy and diagnosis.

Original languageEnglish
Pages (from-to)3223-3229
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Volume13
Issue number5
DOIs
Publication statusPublished - 2013 May 1
Externally publishedYes

Fingerprint

Nanotubes
Cell- and Tissue-Based Therapy
Nanorods
Silicon Dioxide
Gold
nanorods
therapy
Hot Temperature
cancer
Silica
Cells
gold
silicon dioxide
Imaging techniques
Neoplasms
cells
HeLa Cells
Semiconductor Lasers
Raman Spectrum Analysis
hyperthermia

Keywords

  • Au-nanorods
  • Photo-thermal therapy
  • Surface functionalization

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Silica coated gold nanorods for imaging and photo-thermal therapy of cancer cells. / Mallick, Sudipta; Sun, In Cheol; Kim, Kwang Meyung; Yi, Dong Kee.

In: Journal of Nanoscience and Nanotechnology, Vol. 13, No. 5, 01.05.2013, p. 3223-3229.

Research output: Contribution to journalArticle

Mallick, Sudipta ; Sun, In Cheol ; Kim, Kwang Meyung ; Yi, Dong Kee. / Silica coated gold nanorods for imaging and photo-thermal therapy of cancer cells. In: Journal of Nanoscience and Nanotechnology. 2013 ; Vol. 13, No. 5. pp. 3223-3229.
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