Silica gel-supported bis-cinchona alkaloid: A chiral catalyst for the heterogeneous asymmetric desymmetrization of meso-cyclic anhydrides

Yu Mi Song, Jin Seok Choi, Jung Woon Yang, Hogyu Han

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A one-pot conversion of meso-cyclic anhydrides with alcoholysis in diethyl ether using SGS-(DHQ)2AQN 4, a silica gel-supported chiral catalyst, into the corresponding desymmetrized mono ester acids was achieved with enantiomeric excesses of up to 84% under mild and efficient conditions.

Original languageEnglish
Pages (from-to)3301-3304
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number16
DOIs
Publication statusPublished - 2004 Apr 12

Keywords

  • (DHQ)AQN
  • Catalyst immobilization
  • Desymmetrization
  • meso-Cyclic anhydride
  • SGS-(DHQ)AQN

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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