TY - JOUR
T1 - Silk peptide treatment can improve the exercise performance of mice
AU - Kim, Jisu
AU - Hwang, Hyejung
AU - Park, Jonghoon
AU - Yun, Hea Yeon
AU - Suh, Heajung
AU - Lim, Kiwon
N1 - Funding Information:
This study was supported by a grant (NRF-2011-32A-G00050) from the National Research Foundation, which is funded by the Korean Government.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Background: We previously reported that silk peptide (SP) treatment led to increased resting fat oxidation in exercised mice. However, it was not known whether SP treatment could effectively increase exercise capacity. Accordingly, this study aimed to examine whether SP treatment affected energy metabolism during exercise in addition to exercise performance.Methods: We randomized 36 7-week-old male ICR mice into 2 groups: the control (n = 18) and SP (n = 18) groups. All mice were trained by treadmill running 5 times per week for 2 weeks. SP was dissolved in distilled water and daily 800-mg/kg body weight doses before the running exercise were oral administered intraperitoneally to the SP group for 2 weeks. VO2max was measured before and after the 2 weeks training period. We also assessed energy metabolism during exercise for 1 h after the 2 week training period. In addition to blood samples, liver glycogen and gastrocnemius-white and gastrocnemius-red muscle was obtained at the following 3 time points: at rest, immediately after exercise, and 1-hour post exercise.Results: The VO2 max after 2 weeks of training was significantly increased (8%) in the SP group compared to the baseline a similar result was not observed in the CON group. The sum of fat oxidation during a 1-h period tended to be 13% higher in the SP group than in the CON group (P < 0.077). In particular, the sum of fat oxidation was significantly higher in the SP group during the initial 20-min phase than that in the CON group (P < 0.05). The glycogen concentration in the white gastrocnemius muscle did not differ between the groups either rest or after 1 h of exercise but was significantly higher in the SP group than in the CON group during the recovery period (1 h post-exercise completion).Conclusions: These results suggest that SP treatment can improve the exercise performance. Therefore, SP is considered to confer beneficial effects upon athletes, in whom exercise abilities are required.
AB - Background: We previously reported that silk peptide (SP) treatment led to increased resting fat oxidation in exercised mice. However, it was not known whether SP treatment could effectively increase exercise capacity. Accordingly, this study aimed to examine whether SP treatment affected energy metabolism during exercise in addition to exercise performance.Methods: We randomized 36 7-week-old male ICR mice into 2 groups: the control (n = 18) and SP (n = 18) groups. All mice were trained by treadmill running 5 times per week for 2 weeks. SP was dissolved in distilled water and daily 800-mg/kg body weight doses before the running exercise were oral administered intraperitoneally to the SP group for 2 weeks. VO2max was measured before and after the 2 weeks training period. We also assessed energy metabolism during exercise for 1 h after the 2 week training period. In addition to blood samples, liver glycogen and gastrocnemius-white and gastrocnemius-red muscle was obtained at the following 3 time points: at rest, immediately after exercise, and 1-hour post exercise.Results: The VO2 max after 2 weeks of training was significantly increased (8%) in the SP group compared to the baseline a similar result was not observed in the CON group. The sum of fat oxidation during a 1-h period tended to be 13% higher in the SP group than in the CON group (P < 0.077). In particular, the sum of fat oxidation was significantly higher in the SP group during the initial 20-min phase than that in the CON group (P < 0.05). The glycogen concentration in the white gastrocnemius muscle did not differ between the groups either rest or after 1 h of exercise but was significantly higher in the SP group than in the CON group during the recovery period (1 h post-exercise completion).Conclusions: These results suggest that SP treatment can improve the exercise performance. Therefore, SP is considered to confer beneficial effects upon athletes, in whom exercise abilities are required.
KW - Energy metabolism during exercise
KW - Exercise performance
KW - Fat oxidation
KW - Silk peptide
UR - http://www.scopus.com/inward/record.url?scp=84904106986&partnerID=8YFLogxK
U2 - 10.1186/1550-2783-11-35
DO - 10.1186/1550-2783-11-35
M3 - Article
AN - SCOPUS:84904106986
SN - 1550-2783
VL - 11
JO - Journal of the International Society of Sports Nutrition
JF - Journal of the International Society of Sports Nutrition
IS - 1
M1 - 35
ER -