We have tested a silver nano-mesh with close-packed holes as cathodic catalysts for intermediate temperature solid oxide fuel cells. The nano-mesh structure was fabricated in a close-packed hexagonal array with the pore size of 500-600 nm. Fuel cell tests were conducted using the nano-mesh silver cathodes with commercial 100 μm-thick 8% yttria stabilized zirconia electrolytes and sputtered porous platinum anodes. Performance of the fuel cells was analyzed by the current-voltage and the potentiostatic current measurements at temperatures of 250∼300°C. We confirmed that the nano-mesh silver cathodes improved fuel cell performance dramatically and enhanced stability against thermal degradation and morphological agglomeration compared to randomly sputtered porous silver cathodes.